Weak gravitational lensing allows one to reconstruct the spatial distribution of the projected mass density across the sky. These "mass maps" provide a powerful tool for studying cosmology as they probe both luminous and dark matter. In this paper, we present a weak lensing mass map reconstructed from shear measurements in a 139 deg 2 area from the Dark Energy Survey (DES) Science Verification (SV) data overlapping with the South Pole Telescope survey. We compare the distribution of mass with that of the foreground distribution of galaxies and clusters. The overdensities in the reconstructed map correlate well with the distribution of optically detected clusters. Cross-correlating the mass map with the foreground galaxies from the same DES SV data gives results consistent with mock catalogs that include the primary sources of statistical uncertainties in the galaxy, lensing, and photo-z catalogs. The statistical significance of the cross-correlation is at the 6.8 sigma level with 20 arcminute smoothing. A major goal of this study is to investigate systematic effects arising from a variety of sources, including PSF and photo-z uncertainties. We make maps derived from twenty variables that may characterize systematics and find the principal components. We find that the contribution of systematics to the lensing mass maps is generally within measurement uncertainties. We test and validate our results with mock catalogs from N-body simulations. In this work, we analyze less than 3% of the final area that will be mapped by the DES; the tools and analysis techniques developed in this paper can be applied to forthcoming larger datasets from the survey.