Dissemin is shutting down on January 1st, 2025

Published in

Nature Research, Nature Neuroscience, 11(14), p. 1382-1389, 2011

DOI: 10.1038/nn.2963

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Perivascular instruction of cell genesis and fate in the adult brain

Journal article published in 2011 by Steven A. Goldman ORCID, Zhuoxun Chen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The perivascular niche for neurogenesis was first reported as the co-association of newly generated neurons and their progenitors with both dividing and mitotically quiescent endothelial cells in restricted regions of the brain in adult birds and mammals alike. This review attempts to summarize our present understanding of the interaction of blood vessels with neural stem and progenitor cells, addressing both glial and neuronal progenitor cell interactions in the perivascular niche. We review the molecular interactions that are most critical to the endothelial control of stem and progenitor cell mobilization and differentiation. The focus throughout will be on defining those perivascular ligand-receptor interactions shared among these systems, as well as those that clearly differ as a function of cell type and setting, by which specificity may be achieved in the development of targeted therapeutics.