An investigation of plasma enhanced chemical vapour deposition of diamond like carbon deposited on medical grade stainless steel guidewires is presented and contrasted with existing guidewire coating techniques. Raman spectroscopy and atomic force microscopy studies indicate that this novel coating of guidewires, exhibits diamond like characteristics which possess a form of bulk microstructure reflecting the desired low coefficient of friction, high bulk hardness and good substrate bonding properties that are required for medical guidewires.