Published in

EMBO Press, The EMBO Journal, 15(31), p. 3234-3236

DOI: 10.1038/emboj.2012.174

Links

Tools

Export citation

Search in Google Scholar

Divorce of obligatory partners in pain: disruption of GABABreceptor heterodimers in neuralgia

Journal article published in 2012 by Dietmar Benke, Hanns Ulrich Zeilhofer ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

It is now well established that G protein-coupled receptors can exist not only as homodimers, but also as heterodimers or higher order oligomers. However, whether and how dimerization of the receptors is regulated is poorly understood. In this issue of The EMBO Journal, the team of Marc Landry provides evidence for an intriguing mechanism by which—under pathological conditions—GABAB receptor heterodimers at the cell surface are disrupted and thereby inactivated. An impressive set of experiments thus reveals a novel mechanism regulating the number of functional GABAB receptors in the plasma membrane and shows that the receptor heterodimer may not be as stable as we previously thought.