Published in
Public Library of Science, PLoS Genetics, 8(8), p. e1002849, 2012
DOI: 10.1371/journal.pgen.1002849
Links
- ORCID
- Public Library of Science
- [www.ncbi.nlm.nih.gov] | PDF
- [journals.plos.org] | PDF
- [www.research.ed.ac.uk] | PDF
- [www.pure.ed.ac.uk] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
Tools
Variation of BMP3 Contributes to Dog Breed Skull Diversity
,
Brennan Decker,
Jeffrey M. Kidd,
Raman Sood,
Adam R. Boyko,
John W. Fondon,
Robert K. Wayne,
Carlos D. Bustamante,
Brian Ciruna
and other authors.
Full text: Download
Abstract
Since the beginnings of domestication, the craniofacial architecture of the domestic dog has morphed and radiated to human whims. By beginning to define the genetic underpinnings of breed skull shapes, we can elucidate mechanisms of morphological diversification while presenting a framework for understanding human cephalic disorders. Using intrabreed association mapping with museum specimen measurements, we show that skull shape is regulated by at least five quantitative trait loci (QTLs). Our detailed analysis using whole-genome sequencing uncovers a missense mutation in BMP3. Validation studies in zebrafish show that Bmp3 function in cranial development is ancient. Our study reveals the causal variant for a canine QTL contributing to a major morphologic trait.