Published in

American Thoracic Society, American Journal of Respiratory and Critical Care Medicine, 5(185), p. 537-546, 2012

DOI: 10.1164/rccm.201106-0965oc

Links

Tools

Export citation

Search in Google Scholar

Regulation of Transforming Growth Factor-β1–driven Lung Fibrosis by Galectin-3

Journal article published in 2012 by Alison C. MacKinnon, Michael A. Gibbons, Sarah L. Farnworth, Hakon Leffler, Ulf J. Nilsson ORCID, Tamara Delaine, A. John Simpson, A. John Simpson, Stuart J. Forbes ORCID, Nik Hirani, Jack Gauldie, Tariq Sethi
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Red circle
Preprint: archiving forbidden
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic dysregulated response to alveolar epithelial injury with differentiation of epithelial cells and fibroblasts into matrix-secreting myofibroblasts resulting in lung scaring. The prognosis is poor and there are no effective therapies or reliable biomarkers. Galectin-3 is a β-galactoside binding lectin that is highly expressed in fibrotic tissue of diverse etiologies.