Dissemin is shutting down on January 1st, 2025

Published in

MDPI, Viruses, 8(4), p. 1182-1201, 2012

DOI: 10.3390/v4081182

Links

Tools

Export citation

Search in Google Scholar

Herpesvirus Exploitation of Host Immune Inhibitory Pathways

Journal article published in 2012 by Gabrielle Stack ORCID, Maria A. Stacey, Ian R. Humphreys
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Herpesviruses employ a plethora of mechanisms to circumvent clearance by host immune responses. A key feature of mammalian immune systems is the employment of regulatory pathways that limit immune responsiveness. The primary functions of these mechanisms are to control autoimmunity and limit exuberant responses to harmless antigen in mucosal surfaces. However, such pathways can be exploited by viral pathogens to enable acute infection, persistence and dissemination. Herein, we outline the current understanding of inhibitory pathways in modulating antiviral immunity during herpesvirus infections in vivo and discuss strategies employed by herpesviruses to exploit these pathways to limit host antiviral immunity.