Published in
Oxford University Press, Bioinformatics, 13(29), p. i80-i88, 2013
DOI: 10.1093/bioinformatics/btt243
Links
- ORCID
- ORCID
- Oxford University Press
- [www.ncbi.nlm.nih.gov] | PDF
- [eprint.ncl.ac.uk] | PDF
- [serval.unil.ch] | PDF
- [doc.rero.ch] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [my.unil.ch] | PDF
Tools
Hard-wired heterogeneity in blood stem cells revealed using a dynamic regulatory network model
,
Judith Schütte,
Sarah Kinston,
Diego Miranda-Saavedra,
Jaap Heringa,
Ioannis Xenarios ,
Berthold Göttgens
Full text: Download
Abstract
Motivation: Combinatorial interactions of transcription factors with cis-regulatory elements control the dynamic progression through successive cellular states and thus underpin all metazoan development. The construction of network models of cis-regulatory elements, therefore, has the potential to generate fundamental insights into cellular fate and differentiation. Haematopoiesis has long served as a model system to study mammalian differentiation, yet modelling based on experimentally informed cis-regulatory interactions has so far been restricted to pairs of interacting factors. Here, we have generated a Boolean network model based on detailed cis-regulatory functional data connecting 11 haematopoietic stem/progenitor cell (HSPC) regulator genes.