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Elsevier, Polyhedron, 2(26), p. 456-459

DOI: 10.1016/j.poly.2006.07.004

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Radiotracer studies of the antitumor metallocene molybdocene dichloride with biomolecules.

Journal article published in 2007 by Ks Campbell, Ct Dillon, Sv Smith, Margaret Mm Harding ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Neutron irradiation Of Cp2MoCl2 for 24 h afforded the radiotracer (CP2MoCl2)-Mo-99 which was characterised by UV-Vis spectroscopy and thin layer chromatography. Binding experiments with the thiol containing protein human serum albumin (HSA) or calf thymus DNA, were monitored for Mo-99 using a gamma counter. Under the conditions investigated, molar ratios of binding of 0.2:1 (Cp2MoCl2:DNA) and 9.4:1 (Cp2MoCl2:HSA) were calculated. The results are consistent with in vitro coordination studies that have shown strong preferential interaction Of Cp2MoCl2 with thiols versus other donor sites in biomolecules including DNA. (c) 2006 Elsevier Ltd. All rights reserved.