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Elsevier, Tetrahedron Letters, 25(49), p. 4007-4010

DOI: 10.1016/j.tetlet.2008.04.090

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Enantiodivergent synthesis of trans-3,4-disubstituted succinimides by SmI2-mediated Reformatsky-type reaction

This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

An enantiodivergent strategy for the synthesis of traps-3,4-disubstituted succinimides is reported. The key step is a highly trans-stereoselective SmI2-induced Reformatsky-type reaction of 4-substituted-O-benzoylated malimides with carbonyl compounds. Double chirality transmissions were performed with good to excellent diastereoselectivities. (C) 2008 Elsevier Ltd. All rights reserved.