Elsevier, Tetrahedron Letters, 25(49), p. 4007-4010
DOI: 10.1016/j.tetlet.2008.04.090
Full text: Unavailable
An enantiodivergent strategy for the synthesis of traps-3,4-disubstituted succinimides is reported. The key step is a highly trans-stereoselective SmI2-induced Reformatsky-type reaction of 4-substituted-O-benzoylated malimides with carbonyl compounds. Double chirality transmissions were performed with good to excellent diastereoselectivities. (C) 2008 Elsevier Ltd. All rights reserved.