Published in
Public Library of Science, PLoS Genetics, 9(7), p. e1002275, 2011
DOI: 10.1371/journal.pgen.1002275
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Genome-wide association study identifies four loci associated with eruption of permanent teeth
,
Hao Zhang,
Shaffer Jr,
John R. Shaffer,
Thomas Hansen ,
Esserlind Al,
Ann-Louise Esserlind,
Heather A. Boyd,
Boyd Ha,
Nohr Ea,
Ellen A. Nohr,
Timpson Nj,
Nicholas J. Timpson
and other authors.
Full text: Download
Abstract
The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P