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Public Library of Science, PLoS Genetics, 2(6), p. e1000856, 2010

DOI: 10.1371/journal.pgen.1000856

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Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy

Journal article published in 2010 by Greg Gibson, Demetris Pillas, Clive J. Hoggart, David M. Evans, Evans Dm, Paul F. O'Reilly, Kirsi Sipilä, K. Sipil?, Raija Lähdesmäki, Millwood Iy, Iona Y. Millwood, Raija Lahdesmaki, Marika Kaakinen ORCID, Gopalakrishnan Netuveli, R. L?hdesm?ki and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P