Aims: Coronary Artery Disease (CAD) negatively affects prognosis in patients undergoing surgical aortic valve replacement, consequently being appraised in the most common used risk score. Our meta-analysis aims to clarify the association of CAD on mid-term survival in patients undergoing TAVI. Methods and results: A systematic literature review was performed looking for studies reporting multivariate predictors of adverse outcomes in patients undergoing TAVI and pooled, when appropriate, using a random-effect method. 960 citations were first screened and finally 7 studies (2472 patients) were included. Diagnosis of CAD was reported in 37% to 51% of patients and 1169 Edwards SAPIEN and 1303 CoreValve prostheses were implanted. Follow-up time was 452 (357-585) days. After a median follow up of 452 days (357-585) 24% of patients (19-33) died, and 23 (14- 32) for cardiovascular death which was mentioned only in three works At pooled analysis of multivariate approach, diagnosis of coronary artery disease did not increase risk of death (OR 1.0, 95% CI, Confidence Interval, 0.67-1.50). Conclusion: CAD does not affect mid-term TAVI outcome, and this finding should be weighted to accurately evaluate risk and strategies for patients with severe aortic stenosis.