At a moment when regionalisation and regionalism are being widely promoted across a range of policy sectors, this paper argues that much regional activity, including regional environmental management, is often the product of interactions, resources and opportunities at other scales. The paper shows how local and extra-regional interactions, resources and opportunities influence environmental management at the regional level in Australia by the development of a case analysis of Far North Queensland. It finds that much of the current thinking about regionalisation and regionalism ignores these multiscalar dimensions. This can impede and undermine efforts to manage the environment effectively at the regional level. The paper identifies some opportunities to improve regional environmental management activities in Australia and draws out the broader implications for other policy sectors and other countries embracing the movement towards regionalism/regionalisation. The relationship between governance by network at the regional level and the power and control of central government is highlighted. The paper also calls for further research into how governments and other actors successfully manage multiscalar relations of governance in order to promote (or impede) specific public policy initiatives.