Published in

Public Library of Science, PLoS ONE, 2(9), p. e89596, 2014

DOI: 10.1371/journal.pone.0089596

Links

Tools

Export citation

Search in Google Scholar

Highly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array

Journal article published in 2014 by Caroline May, Eckhard Nordhoff, Michael Turewicz, Swaantje Casjens, Martin Eisenacher, Ralf Gold, Thomas Brüning, Dirk Woitalla, Beate Pesch, Christian Stephan, Dezső Virók, Botond Penke, Tamás Janáky ORCID, László Siklós, Jozsef I. Engelhardt and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, is characterized by the progressive and selective loss of upper and lower motor neurons. Diagnosis of this disorder is based on clinical assessment, and the average survival time is less than 3 years. Injections of IgG from ALS patients into mice are known to specifically mark motor neurons. Moreover, IgG has been found in upper and lower motor neurons in ALS patients. These results led us to perform a case-control study using human protein microarrays to identify the antibody profiles of serum samples from 20 ALS patients and 20 healthy controls. We demonstrated high levels of 20 IgG antibodies that distinguished the patients from the controls. These findings suggest that a panel of antibodies may serve as a potential diagnostic biomarker for ALS.