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American Chemical Society, Organic Letters, 22(2), p. 3461-3464, 2000

DOI: 10.1021/ol006484l

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New Peptide Labels Containing Covalently Bonded Platinum(II) Centers as Diagnostic Biomarkers and Biosensors

Journal article published in 2000 by G. van Koten, Martin A. Albrecht ORCID, Gema Rodriguez, Jeroen Schoenmaker, Gerard van Koten
This paper is available in a repository.
This paper is available in a repository.

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Abstract

[reaction: see text] Water- and acid-resistant arylplatinum(II) complexes have been covalently bonded to the N-terminus of L-valine, thus providing organometallic biomolecules with excellent stability properties. Owing to the (195)Pt nucleus (I = (1)/(2)), these building blocks are potentially versatile biomarkers (e.g., MRI). Moreover, they display efficient in vitro biosensor characteristics since they detect SO(2) gas selectively and fully reversibly by an instantaneous change of the spectroscopic properties including a diagnostic (195)Pt NMR signal.