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Public Library of Science, PLoS ONE, 2(7), p. e30894, 2012

DOI: 10.1371/journal.pone.0030894

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RAMTaB : robust alignment of multi-tag bioimages

Journal article published in 2012 by Shan e. Ahmed Raza, Shan-E.-Ahmed Raza ORCID, Ahmad Humayun, Sylvie Abouna, Tim W. Nattkemper ORCID, David B. A. Epstein, Michael Khan, Nasir M. (Nasir Mahmood) Rajpoot
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

For the discovery of protein complexes and of functional protein networks within a cell, alignment of the tag images in a multi-tag fluorescence image stack is a key pre-processing step. The proposed framework is shown to produce accurate alignment results on both real and synthetic data. Our future work will use the aligned multi-channel fluorescence image data for normal and diseased tissue specimens to analyze molecular co-expression patterns and functional protein networks.