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Elsevier, Neuroscience, (300), p. 576-584, 2015

DOI: 10.1016/j.neuroscience.2015.05.048

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The effect of neuronal conditional knock-out of peroxisome proliferator-activated receptors in the MPTP mouse model of Parkinson’s disease

Journal article published in 2015 by Ross B. Mounsey, Heather L. Martin ORCID, Michael C. Nelson, Ronald M. Evans, Peter Teismann
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

•We investigate the role of PPARγ and PPARδ in a model of Parkinson’s disease.•Conditional neuronal knockout of PPARγ or PPARδ did not increase susceptibility to MPTP.•Conditional double knockout of neuronal PPARγ and PPARδ did not enhance MPTP toxicity significantly.•Glial PPAR expression seems more important to confer neuroprotection.