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Wiley Open Access, Molecular Oncology, 1(2), p. 41-53, 2008

DOI: 10.1016/j.molonc.2008.03.006

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Molecular aspects of tumour hypoxia

Journal article published in 2008 by Saskia E. Rademakers, Paul N. Span, Johannes H. A. M. Kaanders, Fred C. G. J. Sweep ORCID, Albert J. van der Kogel, A. J. van der Kogel, Johan Bussink ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Hypoxia is an important feature of the microenvironment of a wide range of solid tumours. Its critical role in radio- and chemoresistance and its significance as an adverse prognostic factor have been well established over the last decades. On a cellular level, hypoxia evokes a complex molecular response with a central role for the HIF-1 pathway. The cellular processes under control of HIF-1 contain important prognostic information and comprise potential candidates for directing hypoxia-modifying therapies. This review will provide an overview of the current knowledge on the molecular aspects of tumour hypoxia and the link to clinical practice.