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Elsevier, Parkinsonism & Related Disorders, 4(14), p. 342-344, 2008

DOI: 10.1016/j.parkreldis.2007.08.012

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CSF hypocretin-1 levels are normal in multiple-system atrophy.

Journal article published in 2008 by W. F. Abdo, B. R. Bloem, H. P. H. Kremer, G. J. Lammers ORCID, M. M. Verbeek, S. Overeem ORCID
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Abstract

Sleep disturbances occur in 70% of the patients with multiple system atrophy (MSA). Disturbances of the hypothalamic hypocretin neurotransmission have been suggested as a possible cause. Since a systematic study of CSF hypocretin-1 levels in MSA has not yet been performed, we analysed CSF hypocretin-1 concentrations in 6 MSA-P and 6 MSA-C patients and 11 age-matched controls. We did not observe any differences from control values.