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Cambridge University Press, Twin Research and Human Genetics, 5(13), p. 405-411, 2010

DOI: 10.1375/twin.13.5.405

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Stringent programming of DNA methylation in humans

Journal article published in 2010 by Hnin T. Aung, Dion K. Harrison, Ian Findlay, John S. Mattick ORCID, Nicholas G. Martin ORCID, Bernard J. Carroll
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We describe a PCR-based method called Amplified Methylation Polymorphism (AMP) for scanning genomes for DNA methylation changes. AMP detects tissue-specific DNA methylation signatures often representing junctions between methylated and unmethylated DNA close to intronexon junctions and/or associated with CpG islands. Identical AMP profiles are detected for healthy, young, monozygotic twins.