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Wiley, Angewandte Chemie International Edition, 25(52), p. 6476-6479, 2013

DOI: 10.1002/anie.201302176

Wiley, Angewandte Chemie, 25(125), p. 6604-6607, 2013

DOI: 10.1002/ange.201302176

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Photosensitization of DNA by 5-Methyl-2-Pyrimidone Deoxyribonucleoside: (6 - 4) Photoproduct as a Possible Trojan Horse

Journal article published in 2013 by Victoria Vendrell-Criado, Gemma M. Rodríguez-Muñiz ORCID, M. Consuelo Cuquerella ORCID, Virginie Lhiaubet-Vallet, Miguel A. Miranda
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

A (photo)sensitive subject: Combined agarose gel electrophoresis and photochemical studies show that 5-methyl-2-pyrimidone (see picture), the main chromophore of (6-4) photoproducts, behaves as a DNA photosensitizer. These results raise the question of whether the (6-4) lesions can act as Trojan horses, enhancing cyclobutane pyrimidine dimer (CPD) formation and oxidative damage. ; Spanish Government (CTQ2009-13699, CTQ2012-32621, RiRAAF RETICS RD12/0013/0009, Ramon y Cajal contract RyC2007-00476 to V.L.-V. and JAE-Predoc 2011-00740 to V.V.-C.). ; Vendrell Criado, V.; Rodríguez Muñiz, GM.; Cuquerella Alabort, MC.; Lhiaubet ., VL.; Miranda Alonso, MÁ. (2013). Photosensitization of DNA by 5-methyl-2pyrimidone deoxyribonucleoside: (6-4) photoproduct as a posible trojan horse. Angewandte Chemie International Edition. 52(25):6476-6479. doi:10.1002/anie.201302176. ; Senia ; 6476 ; 6479 ; 52 ; 25