As part of a multinational program of research, we undertook a community-based participatory research project in Jamaica to strengthen nurses' engagement in HIV and AIDS policy. Three leadership hubs were purposefully convened and included small groups of people (6–10) from diverse HIV and AIDS stakeholder groups in Jamaica: Frontline nurses and nurse managers in primary and secondary care settings; Revised researchers; Revised health care decision makers; Revised and other community members. People living with HIV or AIDS were among the hub members. Using a relational public health ethics framework, we outline some of the ethical challenges and opportunities experienced by the research team and the leadership hubs. Data included research assistant field notes and hub progress reports. Emerging ethical concerns were associated with relational person-hood, social justice, relational autonomy, relational solidarity, and sustainability of the hub activities.