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Elsevier, Cancer Letters, 1(344), p. 138-146

DOI: 10.1016/j.canlet.2013.10.025

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Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes

Journal article published in 2014 by Cathy B. Moelans ORCID, Petra van der Groep, P. van der Groep, Laurien D. C. Hoefnagel, Marc J. van de Vijver, M. J. van de Vijver, Pieter Wesseling ORCID, Jelle Wesseling, Elsken van der Wall, E. van der Wall, Paul J. van Diest, P. J. van Diest
This paper was not found in any repository, but could be made available legally by the author.
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Abstract

Cancer initiation and progression is characterized by (epi)genetic aberrations. However, little is known about the changes that occur during breast cancer metastasis. In the present study, multiplex ligation-dependent probe amplification was used to compare copy numbers of 21 established oncogenes and tumor suppressor genes between 55 primary breast cancer samples and corresponding distant metastases. Distant breast cancer metastases generally showed similar gene copy number aberrations compared to their corresponding primary tumors. The few genes that showed differences between primary tumor and metastasis (PRDM14, MED1, CCNE1, TRAF4, MTDH, CDH1) have been implicated in the development of therapy resistance.