In-flight medical emergencies are becoming a concern to airlines and their passengers in light of the increasing number of air passengers. The SQ flight was from Sydney, Australia to Singapore. The whole journey took about eight hours. Three hours into the flight, a 58-year old woman began complaining of central chest pain radiating to her left arm, shortness of breath, and a dull aching pain in her right lower limb. She described the chest pain as having started like a heavy stone sitting on her chest. The strength of the in-flight medical emergency system and some points are discussed in this article.