Published in

Publishing House Zaslavsky, Gastroenterology, 4(136), p. 1281-1287

DOI: 10.1053/j.gastro.2009.01.003

Links

Tools

Export citation

Search in Google Scholar

Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursodeoxycholic acid.

Journal article published in 2009 by Edith M. M. Kuiper, Jannie W. den Ouden Muller, Bettina E. Hansen ORCID, Richard A. de Vries, R. A. de Vries, J. W. den Ouden-Muller, Theo J. M. van Ditzhuijsen, T. J. van Ditzhuijsen, Els B. Haagsma, Martin H. M. G. Houben, Ben J. M. Witteman, Karel J. van Erpecum, K. J. van Erpecum, H. R. van Buuren, Henk R. van Buuren and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

BACKGROUND & AIMS: Ursodeoxycholic acid (UDCA) improves laboratory liver test results in patients with primary biliary cirrhosis (PBC). Few studies have assessed the prognostic significance of biochemical data collected following UDCA treatment. We performed a prospective multicenter study of patients with PBC treated with UDCA to compare prognosis with biochemical response. METHODS: PBC was classified as early (pretreatment bilirubin and albumin levels normal), moderately advanced (one level abnormal), or advanced (both levels abnormal). Biochemical response was defined as proposed by Pares (decrease in alkaline phosphatase [ALP] level>40% of baseline level or normal level), Corpechot (ALP level