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BioMed Central, BMC Public Health, 1(12), 2012

DOI: 10.1186/1471-2458-12-343

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Prevalence and determinants of chronic kidney disease in community-dwelling elderly by various estimating equations

Journal article published in 2012 by Dietrich Rothenbacher, Jochen Klenk ORCID, Mahir Karakas, Michael Denkinger ORCID, Thorsten Nikolaus, Richard Peter, Wolfgang Koenig, for the ActiFE Study Group
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Chronic kidney disease (CKD) represents a global public health problem. Few data exist in the elderly. The objective of the current study is to estimate the prevalence of CKD by means of various established and new equations and to identify the main determinants of CKD in elderly. Methods The ActiFE Ulm (Activity and Function in the Elderly in Ulm) study is a population-based cohort study in people of 65 years and older. Kidney function was assessed by means of estimated glomerular filtration rate (eGFR) based on two creatinine- (Cr-; MDRD, CKD-EPI) and one cystatin C - (CysC-) based method. The relationship between various potential risk factors and CKD was quantified using unconditional logistic regression. Results A total of 1471 subjects were in the final analysis (mean age 75.6 years, SD 6.56). Overall, prevalence of CKD (eGFR