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Wiley, Chemistry - A European Journal, 26(18), p. 8024-8027, 2012

DOI: 10.1002/chem.201201090

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Reactivity of Nucleosides with a Hydroxyl Radical in Non-aqueous Medium

Journal article published in 2012 by Gemma María Rodríguez Muñiz ORCID, Mª Luisa Marín García, Miguel Ángel Miranda Alonso, Virginie Lyria Lhiaubet, Miguel A. Miranda
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

DNA damage: The reactivity of HO. with silylated 2¿-deoxyribonucleosides was investigated in acetonitrile by means of a time-resolved technique. The obtained rate constants were in general slightly lower than those reported for the natural nucleosides in water. Analysis of the reaction mixture by UPLC-MS revealed that HO. attack occurred at the nucleobase (see scheme). ; Rodríguez Muñiz, GM.; Marín García, ML.; Miranda Alonso, MÁ.; Lhiaubet, VL. (2012). Reactivity of Nucleosides with a Hydroxyl Radical in Non-aqueous Medium. Chemistry - A European Journal. 18:8024-8027. doi:10.1002/chem.201201090. ; Senia ; 8024 ; 8027 ; 18