Dissemin is shutting down on January 1st, 2025

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Springer Verlag, Journal of Neurology, 6(243), p. 465-468

DOI: 10.1007/bf00900501

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Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease.

Journal article published in 1996 by Cornelia M. van Duijn, Peter de Knijff ORCID, Christine Van Broeckhoven, Juliana B. (Juliana) Bronzova, Cornelia M. (Cock) van Duijn, Louis M. (Louis) Havekes, P. (Peter) de Knijff, C. (Christine) van Broeckhoven, A. (Albert) Hofman
This paper is available in a repository.
This paper is available in a repository.

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Abstract

We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This allele was also associated with an increased risk of myoclonus. Our findings suggest that there may be differences in progression and clinical appearance in early-onset AD related to the APOE genotype.