Quinoline carboxamide-type ABCG2 modulators: Indole and quinoline moieties as anilide replacements
Journal article published in 2013 by
Stefanie Bauer,
Cristian Ochoa Puentes,
Qiu Sun 
,
Manuel Bause,
Günther Bernhardt,
Burkhard König,
Armin Buschauer
,
Manuel Bause,
Günther Bernhardt,
Burkhard König,
Armin Buschauer
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Abstract
Bioisosteric replacement of the anilide core by an indole moiety considerably increased stability and gave potent and selective ABCG2 (BCRP) inhibitors. Some compounds are superior to the reference substances fumitremorgin C and Ko143 in terms of potency and efficacy and are the most potent ABCG2 modulators reported so far.