A combined experimental and computational investigation has been performed in order to evaluate the influence of physical properties of biodiesel on the injection process in a common-direct injection system with second generation solenoid injectors. For that purpose, after a complete characterization of the system, which involved mechanical and hydraulic characterization, a one-dimensional model has been obtained and extensively validated. Simulations have then been performed with a standard diesel and a 100% rape methyl ester (RME) biodiesel which allowed a comparison and analysis of the dynamic response of the injector to be done. Different injection strategies involving main injection and main plus post-injection have been used to explore the impact of the use of biodiesel on the performance and stability of solenoid injectors. As far as the dynamic response of the injector is concerned, the results obtained have clearly shown that the use of biodiesel affects the dynamic response of the needle, especially at low injection pressures. The behavior of the system under multi-injection strategies (main plus post-injection) has been also evaluated determining for different operating conditions (injection pressures and backpressures) the minimum dwell time between injections to assure a stable behavior in the injection process (mass flow rate). Important differences have been found between biodiesel and standard diesel in this critical parameter at low injection pressures, becoming less important at high injection pressure. Finally, a modification on the injector hardware has been proposed in order to compensate these differences. ; Ministerio de Ciencia e Innovación in the frame of the project ‘‘Estudio teórico experimental de la influencia del combustible sobre la cavitación y el desarrollo del chorro evaporative (FlexiFuel)’’, Reference TRA2010-17564 ; Payri Marín, R.; Salvador Rubio, FJ.; Marti Aldaravi, P.; Martínez López, J. (2012). Using one-dimensional modeling to analyse the influence of the use of biodiesels on the dynamic behavior of solenoid-operated injectors in common rail systems: Detailed injection system model. Energy Conversion and Management. 54(1):90-99. doi:10.1016/j.enconman.2011.10.004. ; Senia ; 90 ; 99 ; 54 ; 1