Discovery and Refinement of Loci Associated with Lipid Levels

Willer, Cristen J.; Van den Herik, Evita G.; WWiller, CJ;Schmidt EM;Sengupta S;Peloso GM;Gustafsson S;Kanoni S;Ganna A;Chen J;Buchkovich ML;Mora S;Beckmann JS;Bragg-Gresham Jl;Chang Hy;Demirkan A;Den Hertog HM;Do R;Donnelly LA;Ehret GB;Esko T;Feitosa MF;Ferreira T;Fischer K;Fontanillas P;Fraser RM;Freitag DF;; Schmidt, Ellen M.; Van Pelt, L. J.; Peloso, Gina M.; Service, Susan K.; Shah, Sonia; Shungin, Dmitry; Buchkovich, Martin L.; Sidore, Carlo; Sengupta, Sebanti; Song, Ci; Beckmann, Jacques S.; Strawbridge, Rona J.; Bragg-Gresham, Jennifer L.; Surakka, Ida; Chang, Hsing-Yi; Tanaka, Toshiko; Teslovich, Tanya M.; Den Hertog, Heleen M.; Thorleifsson, Gudmar; Donnelly, Louise A.; Ehret, Georg B.; Voight, Benjamin F.; Volcik, Kelly A.; Waite, Lindsay Ll; Feitosa, Mary F.; Wong, Andrew; Ferreira, Teresa; Wu, Ying; Fischer, Krista; Zhang, Weihua; Fontanillas, Pierre; Van Duijn, C. M.; Fraser, Ross M.; Freitag, Daniel F.; Gustafsson, Stefan; Gurdasani, Deepti; Heikkilä, Kauko; Kanoni, Stavroula; Hyppönen, Elina; Isaacs, Aaron; Jackson, Anne U.; Johansson, Å.; Johnson, Toby; Demirkan, Ayşe; Kaakinen, Marika; Sanna, Serena; Kettunen, Johannes; Cj, Willer; Ganna, Andrea; Kleber, Marcus E.; Saxena, Richa; Li, Xiaohui; Luan, Jian’an; Lyytikäinen, Leo-Pekka; Magnusson, Patrik K. E.; Mangino, Massimo; Mihailov, Evelin; Montasser, May E.; Müller-Nurasyid, Martina; Chen, Jin; Do, Ron; Nolte, Ilja M.; O'Connell, Jeffrey R.; Palmer, Cameron D.; Perola, Markus; Petersen, Ann-Kristin; van Pelt, Lj Joost; Em, Schmidt; Esko, Tõnu; Silander, Kaisa; Mora, Samia; Johansson, Åsa; Stančáková, Alena; Stirrups, Kathleen; Swift, Amy J.; Tiret, Laurence; Absher, Devin; Uitterlinden, Andre G.; Asiki, Gershim; Vedantam, Sailaja; Barroso, Inês; Wainwright, Nicholas; Been, Latonya F.; de Faire, Ulf; Wijmenga, Cisca; Bolton, Jennifer L.; Wild, Sarah H.; Willemsen, Gonneke; Bonnycastle, Lori Ll; Wilsgaard, Tom; Wilson, James F.; Gm, Peloso; Brambilla, Paolo; Young, Elizabeth H.; Burnett, Mary S.; Zhao, Jing Hua; Cesana, Giancarlo; Dimitriou, Maria; Doney, Alex S. F.; Döring, Angela; Elliott, Paul; Epstein, Stephen E.; Gigante, Bruna; Goodarzi, Mark O.; Grallert, Harald; Gravito, Martha L.; Groves, Christopher J.; Hallmans, Göran; Hartikainen, Anna-Liisa; Rader, Daniel J.; Hayward, Caroline; Hernandez, Dena; Reilly, Muredach P.; Hicks, Andrew Aa; Holm, Hilma; Ridker, Paul M.; Hung, Yi-Jen; Rivadeneira, Fernando; Illig, Thomas; Rudan, Igor; Jones, Michelle R.; Eyjolfsson, Gudmundur Ingi; Kaleebu, Pontiano; Ruokonen, Aimo; Kastelein, John J. P.; Samani, Nilesh; Khaw, Kay-Tee; Kim, Eric; Scharnagl, Hubert; Klopp, Norman; Seeley, Janet; Komulainen, Pirjo; van Duijn, Cornelia M.; Johansson, Åsa; Kumari, Meena; Langenberg, Claudia; Hyppoenen, Elina; Lehtimäki, Terho; Lin, Shih-Yi; Lindström, Jaana; Ingi Eyjolfsson, Gudmundur; Loos, Ruth J. F.; Mach, François; McArdle, Wendy L.; Meisinger, Christa; Mitchell, Braxton D.; Sheu, Wayne H.-H.; Müller, Gabrielle; Shuldiner, Alan R.; Nagaraja, Ramaiah; Siegbahn, Agneta; Narisu, Narisu; Spector, Tim D.; Nieminen, Tuomo V. M.; Stefansson, Kari; Nsubuga, Rebecca N.; Strachan, David P.; Muller-Nurasyid, Martina; Tayo, Bamidele O.; Olafsson, Isleifur; Tremoli, Elena; Ong, Ken Kk; Tuomilehto, Jaakko; Uusitupa, Matti; Palotie, Aarno; Vollenweider, Peter; Papamarkou, Theodore; O’connell, Jeffrey R.; Wallentin, Lars; Pomilla, Cristina; Wareham, Nicholas J.; Whitfield, John B.; Pouta, Anneli; Wolffenbuttel, Bruce H. R.; Thorsteinsdottir, Unnur; Mueller-Nurasyid, Martina; Müller-Nurasyid, Martina; Adair, Linda S.; Arveiler, Dominique; Assimes, Themistocles L.; Bandinelli, Stefania; Bennett, Franklyn; Bochud, Murielle; Boehm, Bernhard O.; Boomsma, Dorret I.; Borecki, Ingrid B.; Bornstein, Stefan R.; Bovet, Pascal; Burnier, Michel; Campbell, Harry; Ml, Buchkovich; Chakravarti, Aravinda; Chambers, John C.; Chen, Yii-Der Ida; Collins, Francis S.; Cooper, Richard S.; Danesh, John; Dedoussis, George; Feranil, Alan B.; Ferrieres, Jean; Doering, Angela; Ferrucci, Luigi; Freimer, Nelson B.; Psaty, Bruce M.; Gieger, Christian; Groop, Leif C.; Quertermous, Thomas; Muller, Gabrielle; Gudnason, Vilmundur; Rauramaa, Rainer; Gyllensten, Ulf; Hamsten, Anders; Saleheen, Danish; Mueller, Gabrielle; Harris, Tamara B.; Salomaa, Veikko; Hingorani, Aroon; Hirschhorn, Joel N.; De Faire, U.; Sanghera, Dharambir K.; Hofman, Albert; Saramies, Jouko; Hovingh, Gk Kees; Schwarz, Peter E. H.; Joost van Pelt, L.; Hsiung, Chao Agnes; Humphries, Steve E.; Hunt, Steven C.; Hy, Chang; Hveem, Kristian; Iribarren, Carlos; Järvelin, Marjo-Riitta; Jula, Antti; Kähönen, Mika; Kaprio, Jaakko; Js, Beckmann; Kesäniemi, Antero; Kivimaki, Mika; Kooner, Jaspal S.; Koudstaal, Peter J.; Rotter, Jerome I.; Krauss, Ronald M.; Ripatti, Samuli; Consortium, Global Lipids Genetics; Kuh, Diana; Kuusisto, Johanna; Sandhu, Manjinder S.; Kyvik, Kirsten O.; Rich, Stephen Ss; Laakso, Markku; Lakka, Timo A.; Lind, Lars; Lindgren, Cecilia M.; Martin, Nicholas G.; März, Winfried; McCarthy, Mark I.; Mckenzie, Colin A.; Meneton, Pierre; Jl, Bragg Gresham; Metspalu, Andres; Kees Hovingh, G.; Moilanen, Leena; Morris, Andrew D.; Munroe, Patricia B.; Njølstad, Inger; Hm, Den Hertog; Pedersen, Nancy L.; Power, Chris; Pramstaller, Peter Pp; Price, Jackie F.; La, Donnelly; Ordovas, Jose M.; Jarvelin, Marjo-Riitta; Kahonen, Mika; Boerwinkle, Eric; Palmer, Colin N. A.; März, Winfried; Chasman, Daniel I.; Gb, Ehret; Franks, Paul W.; Maerz, Winfried; Cupples, La Adrienne; Adrienne Cupples, L.; Boehnke, Michael; Deloukas, Panos; Kathiresan, Sekar; Mohlke, Karen L.; Ingelsson, Erik; Abecasis, Gonçalo R.

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Carlo Sidore
Willer et al., 2013

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@article{Willer2013,
  abstract = {Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P &lt; 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.},
  author = {Willer, Cristen J. and Van den Herik, Evita G. and WWiller, CJ;Schmidt EM;Sengupta S;Peloso GM;Gustafsson S;Kanoni S;Ganna A;Chen J;Buchkovich ML;Mora S;Beckmann JS;Bragg-Gresham Jl;Chang Hy;Demirkan A;Den Hertog HM;Do R;Donnelly LA;Ehret GB;Esko T;Feitosa MF;Ferreira T;Fischer K;Fontanillas P;Fraser RM;Freitag DF; and Schmidt, Ellen M. and Van Pelt, L. J. and Peloso, Gina M. and Service, Susan K. and Shah, Sonia and Shungin, Dmitry and Buchkovich, Martin L. and Sidore, Carlo and Sengupta, Sebanti and Song, Ci and Beckmann, Jacques S. and Strawbridge, Rona J. and Bragg-Gresham, Jennifer L. and Surakka, Ida and Chang, Hsing-Yi and Tanaka, Toshiko and Teslovich, Tanya M. and Den Hertog, Heleen M. and Thorleifsson, Gudmar and Donnelly, Louise A. and Ehret, Georg B. and Voight, Benjamin F. and Volcik, Kelly A. and Waite, Lindsay Ll and Feitosa, Mary F. and Wong, Andrew and Ferreira, Teresa and Wu, Ying and Fischer, Krista and Zhang, Weihua and Fontanillas, Pierre and Van Duijn, C. M. and Fraser, Ross M. and Freitag, Daniel F. and Gustafsson, Stefan and Gurdasani, Deepti and Heikkilä, Kauko and Kanoni, Stavroula and Hyppönen, Elina and Isaacs, Aaron and Jackson, Anne U. and Johansson, Å. and Johnson, Toby and Demirkan, Ayşe and Kaakinen, Marika and Sanna, Serena and Kettunen, Johannes and Cj, Willer and Ganna, Andrea and Kleber, Marcus E. and Saxena, Richa and Li, Xiaohui and Luan, Jian’an and Lyytikäinen, Leo-Pekka and Magnusson, Patrik K. E. and Mangino, Massimo and Mihailov, Evelin and Montasser, May E. and Müller-Nurasyid, Martina and Chen, Jin and Do, Ron and Nolte, Ilja M. and O'Connell, Jeffrey R. and Palmer, Cameron D. and Perola, Markus and Petersen, Ann-Kristin and van Pelt, Lj Joost and Em, Schmidt and Esko, Tõnu and Silander, Kaisa and Mora, Samia and Johansson, Åsa and Stančáková, Alena and Stirrups, Kathleen and Swift, Amy J. and Tiret, Laurence and Absher, Devin and Uitterlinden, Andre G. and Asiki, Gershim and Vedantam, Sailaja and Barroso, Inês and Wainwright, Nicholas and Been, Latonya F. and de Faire, Ulf and Wijmenga, Cisca and Bolton, Jennifer L. and Wild, Sarah H. and Willemsen, Gonneke and Bonnycastle, Lori Ll and Wilsgaard, Tom and Wilson, James F. and Gm, Peloso and Brambilla, Paolo and Young, Elizabeth H. and Burnett, Mary S. and Zhao, Jing Hua and Cesana, Giancarlo and Dimitriou, Maria and Doney, Alex S. F. and Döring, Angela and Elliott, Paul and Epstein, Stephen E. and Gigante, Bruna and Goodarzi, Mark O. and Grallert, Harald and Gravito, Martha L. and Groves, Christopher J. and Hallmans, Göran and Hartikainen, Anna-Liisa and Rader, Daniel J. and Hayward, Caroline and Hernandez, Dena and Reilly, Muredach P. and Hicks, Andrew Aa and Holm, Hilma and Ridker, Paul M. and Hung, Yi-Jen and Rivadeneira, Fernando and Illig, Thomas and Rudan, Igor and Jones, Michelle R. and Eyjolfsson, Gudmundur Ingi and Kaleebu, Pontiano and Ruokonen, Aimo and Kastelein, John J. P. and Samani, Nilesh and Khaw, Kay-Tee and Kim, Eric and Scharnagl, Hubert and Klopp, Norman and Seeley, Janet and Komulainen, Pirjo and van Duijn, Cornelia M. and Johansson, Åsa and Kumari, Meena and Langenberg, Claudia and Hyppoenen, Elina and Lehtimäki, Terho and Lin, Shih-Yi and Lindström, Jaana and Ingi Eyjolfsson, Gudmundur and Loos, Ruth J. F. and Mach, François and McArdle, Wendy L. and Meisinger, Christa and Mitchell, Braxton D. and Sheu, Wayne H.-H. and Müller, Gabrielle and Shuldiner, Alan R. and Nagaraja, Ramaiah and Siegbahn, Agneta and Narisu, Narisu and Spector, Tim D. and Nieminen, Tuomo V. M. and Stefansson, Kari and Nsubuga, Rebecca N. and Strachan, David P. and Muller-Nurasyid, Martina and Tayo, Bamidele O. and Olafsson, Isleifur and Tremoli, Elena and Ong, Ken Kk and Tuomilehto, Jaakko and Uusitupa, Matti and Palotie, Aarno and Vollenweider, Peter and Papamarkou, Theodore and O’connell, Jeffrey R. and Wallentin, Lars and Pomilla, Cristina and Wareham, Nicholas J. and Whitfield, John B. and Pouta, Anneli and Wolffenbuttel, Bruce H. R. and Thorsteinsdottir, Unnur and Mueller-Nurasyid, Martina and Müller-Nurasyid, Martina and Adair, Linda S. and Arveiler, Dominique and Assimes, Themistocles L. and Bandinelli, Stefania and Bennett, Franklyn and Bochud, Murielle and Boehm, Bernhard O. and Boomsma, Dorret I. and Borecki, Ingrid B. and Bornstein, Stefan R. and Bovet, Pascal and Burnier, Michel and Campbell, Harry and Ml, Buchkovich and Chakravarti, Aravinda and Chambers, John C. and Chen, Yii-Der Ida and Collins, Francis S. and Cooper, Richard S. and Danesh, John and Dedoussis, George and Feranil, Alan B. and Ferrieres, Jean and Doering, Angela and Ferrucci, Luigi and Freimer, Nelson B. and Psaty, Bruce M. and Gieger, Christian and Groop, Leif C. and Quertermous, Thomas and Muller, Gabrielle and Gudnason, Vilmundur and Rauramaa, Rainer and Gyllensten, Ulf and Hamsten, Anders and Saleheen, Danish and Mueller, Gabrielle and Harris, Tamara B. and Salomaa, Veikko and Hingorani, Aroon and Hirschhorn, Joel N. and De Faire, U. and Sanghera, Dharambir K. and Hofman, Albert and Saramies, Jouko and Hovingh, Gk Kees and Schwarz, Peter E. H. and Joost van Pelt, L. and Hsiung, Chao Agnes and Humphries, Steve E. and Hunt, Steven C. and Hy, Chang and Hveem, Kristian and Iribarren, Carlos and Järvelin, Marjo-Riitta and Jula, Antti and Kähönen, Mika and Kaprio, Jaakko and Js, Beckmann and Kesäniemi, Antero and Kivimaki, Mika and Kooner, Jaspal S. and Koudstaal, Peter J. and Rotter, Jerome I. and Krauss, Ronald M. and Ripatti, Samuli and Consortium, Global Lipids Genetics and Kuh, Diana and Kuusisto, Johanna and Sandhu, Manjinder S. and Kyvik, Kirsten O. and Rich, Stephen Ss and Laakso, Markku and Lakka, Timo A. and Lind, Lars and Lindgren, Cecilia M. and Martin, Nicholas G. and März, Winfried and McCarthy, Mark I. and Mckenzie, Colin A. and Meneton, Pierre and Jl, Bragg Gresham and Metspalu, Andres and Kees Hovingh, G. and Moilanen, Leena and Morris, Andrew D. and Munroe, Patricia B. and Njølstad, Inger and Hm, Den Hertog and Pedersen, Nancy L. and Power, Chris and Pramstaller, Peter Pp and Price, Jackie F. and La, Donnelly and Ordovas, Jose M. and Jarvelin, Marjo-Riitta and Kahonen, Mika and Boerwinkle, Eric and Palmer, Colin N. A. and März, Winfried and Chasman, Daniel I. and Gb, Ehret and Franks, Paul W. and Maerz, Winfried and Cupples, La Adrienne and Adrienne Cupples, L. and Boehnke, Michael and Deloukas, Panos and Kathiresan, Sekar and Mohlke, Karen L. and Ingelsson, Erik and Abecasis, Gonçalo R.},
  doi = {10.1038/ng.2797},
  month = {oct},
  title = {Discovery and Refinement of Loci Associated with Lipid Levels},
  url = {http://ir.nhri.org.tw/bitstream/3990099045/7633/1/SCP84887099827.pdf},
  year = {2013}
}

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Discovery and Refinement of Loci Associated with Lipid Levels

Journal article published in 2013 by Cristen J. Willer, Evita G. Van den Herik, CJ;Schmidt EM;Sengupta S;Peloso GM;Gustafsson S;Kanoni S;Ganna A;Chen J;Buchkovich ML;Mora S;Beckmann JS;Bragg-Gresham Jl;Chang Hy;Demirkan A;Den Hertog HM;Do R;Donnelly LA;Ehret GB;Esko T;Feitosa MF;Ferreira T;Fischer K;Fontanillas P;Fraser RM;Freitag DF; WWiller, Ellen M. Schmidt, L. J. Van Pelt, Gina M. Peloso, Susan K. Service, Sonia Shah, Dmitry Shungin, Martin L. Buchkovich, Carlo Sidore

, Sebanti Sengupta, Ci Song, Jacques S. Beckmann, Rona J. Strawbridge

and other authors. Cristen J. Willer, Evita G. Van den Herik, CJ;Schmidt EM;Sengupta S;Peloso GM;Gustafsson S;Kanoni S;Ganna A;Chen J;Buchkovich ML;Mora S;Beckmann JS;Bragg-Gresham Jl;Chang Hy;Demirkan A;Den Hertog HM;Do R;Donnelly LA;Ehret GB;Esko T;Feitosa MF;Ferreira T;Fischer K;Fontanillas P;Fraser RM;Freitag DF; WWiller, Ellen M. Schmidt, L. J. Van Pelt, Gina M. Peloso, Susan K. Service, Sonia Shah, Dmitry Shungin, Martin L. Buchkovich, Carlo Sidore

, Sebanti Sengupta, Ci Song, Jacques S. Beckmann, Rona J. Strawbridge

, Jennifer L. Bragg-Gresham, Ida Surakka, Hsing-Yi Chang, Toshiko Tanaka, Tanya M. Teslovich, Heleen M. Den Hertog, Gudmar Thorleifsson, Louise A. Donnelly, Georg B. Ehret, Benjamin F. Voight, Kelly A. Volcik, Lindsay Ll Waite, Mary F. Feitosa, Andrew Wong, Teresa Ferreira, Ying Wu, Krista Fischer, Weihua Zhang, Pierre Fontanillas, C. M. Van Duijn, Ross M. Fraser, Daniel F. Freitag, Stefan Gustafsson, Deepti Gurdasani

, Kauko Heikkilä, Stavroula Kanoni

, Elina Hyppönen

, Aaron Isaacs, Anne U. Jackson, Å. Johansson, Toby Johnson

, Ayşe Demirkan, Marika Kaakinen

, Serena Sanna

, Johannes Kettunen, Willer Cj, Andrea Ganna

, Marcus E. Kleber, Richa Saxena, Xiaohui Li, Jian’an Luan, Leo-Pekka Lyytikäinen, Patrik K. E. Magnusson, Massimo Mangino, Evelin Mihailov, May E. Montasser, Martina Müller-Nurasyid, Jin Chen, Ron Do, Ilja M. Nolte, Jeffrey R. O'Connell, Cameron D. Palmer, Markus Perola, Ann-Kristin Petersen, Lj Joost van Pelt, Schmidt Em, Tõnu Esko

, Kaisa Silander, Samia Mora, Åsa Johansson, Alena Stančáková, Kathleen Stirrups, Amy J. Swift, Laurence Tiret, Devin Absher, Andre G. Uitterlinden, Gershim Asiki, Sailaja Vedantam, Inês Barroso, Nicholas Wainwright, Latonya F. Been, Ulf de Faire, Cisca Wijmenga

, Jennifer L. Bolton, Sarah H. Wild, Gonneke Willemsen, Lori Ll Bonnycastle, Tom Wilsgaard, James F. Wilson, Peloso Gm, Paolo Brambilla, Elizabeth H. Young, Mary S. Burnett, Jing Hua Zhao, Giancarlo Cesana, Maria Dimitriou, Alex S. F. Doney, Angela Döring, Paul Elliott, Stephen E. Epstein, Bruna Gigante

, Mark O. Goodarzi, Harald Grallert, Martha L. Gravito, Christopher J. Groves, Göran Hallmans, Anna-Liisa Hartikainen, Daniel J. Rader, Caroline Hayward, Dena Hernandez, Muredach P. Reilly, Andrew Aa Hicks, Hilma Holm, Paul M. Ridker, Yi-Jen Hung, Fernando Rivadeneira, Thomas Illig, Igor Rudan, Michelle R. Jones, Gudmundur Ingi Eyjolfsson, Pontiano Kaleebu, Aimo Ruokonen, John J. P. Kastelein, Nilesh Samani, Kay-Tee Khaw, Eric Kim, Hubert Scharnagl, Norman Klopp, Janet Seeley, Pirjo Komulainen, Cornelia M. van Duijn, Åsa Johansson, Meena Kumari, Claudia Langenberg, Elina Hyppoenen, Terho Lehtimäki, Shih-Yi Lin, Jaana Lindström

, Gudmundur Ingi Eyjolfsson, Ruth J. F. Loos, François Mach, Wendy L. McArdle, Christa Meisinger

, Braxton D. Mitchell, Wayne H.-H. Sheu, Gabrielle Müller, Alan R. Shuldiner, Ramaiah Nagaraja, Agneta Siegbahn, Narisu Narisu, Tim D. Spector, Tuomo V. M. Nieminen, Kari Stefansson, Rebecca N. Nsubuga, David P. Strachan, Martina Muller-Nurasyid, Bamidele O. Tayo, Isleifur Olafsson, Elena Tremoli, Ken Kk Ong, Jaakko Tuomilehto, Matti Uusitupa, Aarno Palotie, Peter Vollenweider, Theodore Papamarkou, Jeffrey R. O’connell, Lars Wallentin, Cristina Pomilla, Nicholas J. Wareham, John B. Whitfield, Anneli Pouta, Bruce H. R. Wolffenbuttel, Unnur Thorsteinsdottir, Martina Mueller-Nurasyid, Martina Müller-Nurasyid, Linda S. Adair, Dominique Arveiler, Themistocles L. Assimes, Stefania Bandinelli, Franklyn Bennett, Murielle Bochud, Bernhard O. Boehm, Dorret I. Boomsma, Ingrid B. Borecki, Stefan R. Bornstein, Pascal Bovet

, Michel Burnier, Harry Campbell, Buchkovich Ml, Aravinda Chakravarti, John C. Chambers, Yii-Der Ida Chen, Francis S. Collins, Richard S. Cooper, John Danesh, George Dedoussis, Alan B. Feranil, Jean Ferrieres, Angela Doering, Luigi Ferrucci, Nelson B. Freimer, Bruce M. Psaty, Christian Gieger

, Leif C. Groop, Thomas Quertermous, Gabrielle Muller, Vilmundur Gudnason, Rainer Rauramaa, Ulf Gyllensten, Anders Hamsten, Danish Saleheen, Gabrielle Mueller, Tamara B. Harris, Veikko Salomaa, Aroon Hingorani, Joel N. Hirschhorn, U. De Faire, Dharambir K. Sanghera, Albert Hofman, Jouko Saramies, Gk Kees Hovingh, Peter E. H. Schwarz, L. Joost van Pelt, Chao Agnes Hsiung, Steve E. Humphries, Steven C. Hunt, Chang Hy, Kristian Hveem, Carlos Iribarren, Marjo-Riitta Järvelin, Antti Jula, Mika Kähönen, Jaakko Kaprio, Beckmann Js, Antero Kesäniemi, Mika Kivimaki

, Jaspal S. Kooner, Peter J. Koudstaal, Jerome I. Rotter, Ronald M. Krauss, Samuli Ripatti, Global Lipids Genetics Consortium, Diana Kuh, Johanna Kuusisto, Manjinder S. Sandhu, Kirsten O. Kyvik, Stephen Ss Rich, Markku Laakso, Timo A. Lakka, Lars Lind, Cecilia M. Lindgren, Nicholas G. Martin

, Winfried März, Mark I. McCarthy, Colin A. Mckenzie, Pierre Meneton, Bragg Gresham Jl, Andres Metspalu, G. Kees Hovingh, Leena Moilanen, Andrew D. Morris, Patricia B. Munroe, Inger Njølstad, Den Hertog Hm, Nancy L. Pedersen, Chris Power, Peter Pp Pramstaller

, Jackie F. Price

, Donnelly La, Jose M. Ordovas, Marjo-Riitta Jarvelin, Mika Kahonen, Eric Boerwinkle, Colin N. A. Palmer, Winfried März, Daniel I. Chasman, Ehret Gb, Paul W. Franks, Winfried Maerz, La Adrienne Cupples, L. Adrienne Cupples, Michael Boehnke, Panos Deloukas, Sekar Kathiresan, Karen L. Mohlke, Erik Ingelsson, Gonçalo R. Abecasis

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Abstract

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

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Discovery and Refinement of Loci Associated with Lipid Levels

Abstract