Discovery and Refinement of Loci Associated with Lipid Levels

van Pelt, Lj Joost; de Faire, Ulf; van Duijn, Cornelia M.; Willer, Cristen J.; Van den Herik, Evita G.; Service, Susan K.; Shah, Sonia; Shungin, Dmitry; Sidore, Carlo; Song, Ci; WWiller, CJ;Schmidt EM;Sengupta S;Peloso GM;Gustafsson S;Kanoni S;Ganna A;Chen J;Buchkovich ML;Mora S;Beckmann JS;Bragg-Gresham Jl;Chang Hy;Demirkan A;Den Hertog HM;Do R;Donnelly LA;Ehret GB;Esko T;Feitosa MF;Ferreira T;Fischer K;Fontanillas P;Fraser RM;Freitag DF;; Strawbridge, Rona J.; Surakka, Ida; Tanaka, Toshiko; Teslovich, Tanya M.; Thorleifsson, Gudmar; Van Den Herik, E. G.; Voight, Benjamin F.; Volcik, Kelly A.; Waite, Lindsay Ll; Wong, Andrew; Wu, Ying; Zhang, Weihua; Silander, Kaisa; Stančáková, Alena; Stirrups, Kathleen; Swift, Amy J.; Tiret, Laurence; Van Pelt, L. J.; Uitterlinden, Andre G.; Vedantam, Sailaja; Wainwright, Nicholas; Wijmenga, Cisca; Wild, Sarah H.; Willemsen, Gonneke; Wilsgaard, Tom; Wilson, James F.; Young, Elizabeth H.; Zhao, Jing Hua; Sheu, Wayne H.-H.; Shuldiner, Alan R.; Siegbahn, Agneta; Spector, Tim D.; Stefansson, Kari; Strachan, David P.; Tayo, Bamidele O.; Tremoli, Elena; Tuomilehto, Jaakko; Uusitupa, Matti; Van Duijn, C. M.; Vollenweider, Peter; Wallentin, Lars; Wareham, Nicholas J.; Whitfield, John B.; Wolffenbuttel, Bruce H. R.; Thorsteinsdottir, Unnur; Cj, Willer; Schmidt, Ellen M.; Sengupta, Sebanti; Sanna, Serena; Saxena, Richa; Rader, Daniel J.; Reilly, Muredach P.; Ridker, Paul M.; Rivadeneira, Fernando; Rudan, Igor; Ruokonen, Aimo; Samani, Nilesh; Scharnagl, Hubert; Em, Schmidt; Seeley, Janet; Psaty, Bruce M.; Quertermous, Thomas; Rauramaa, Rainer; Saleheen, Danish; Salomaa, Veikko; Sanghera, Dharambir K.; Saramies, Jouko; Schwarz, Peter E. H.; Rotter, Jerome I.; Ripatti, Samuli; Sandhu, Manjinder S.; Rich, Stephen Ss; Consortium, Global Lipids Genetics; Peloso, Gina M.; Johansson, Å.; Buchkovich, Martin L.; Beckmann, Jacques S.; Bragg-Gresham, Jennifer L.; Chang, Hsing-Yi; Den Hertog, Heleen M.; Donnelly, Louise A.; Ehret, Georg B.; Feitosa, Mary F.; Ferreira, Teresa; Fischer, Krista; Fontanillas, Pierre; Fraser, Ross M.; Freitag, Daniel F.; Gm, Peloso; Gurdasani, Deepti; Heikkilä, Kauko; Gustafsson, Stefan; Hyppönen, Elina; Isaacs, Aaron; Jackson, Anne U.; Johnson, Toby; Kaakinen, Marika; Kettunen, Johannes; Kleber, Marcus E.; Li, Xiaohui; Luan, Jian’an; Lyytikäinen, Leo-Pekka; Magnusson, Patrik K. E.; Mangino, Massimo; Kanoni, Stavroula; Mihailov, Evelin; Montasser, May E.; Müller-Nurasyid, Martina; Nolte, Ilja M.; O'Connell, Jeffrey R.; Palmer, Cameron D.; Perola, Markus; Petersen, Ann-Kristin; Johansson, Åsa; Hyppoenen, Elina; Johansson, Åsa; Ganna, Andrea; Absher, Devin; Asiki, Gershim; Barroso, Inês; Been, Latonya F.; Bolton, Jennifer L.; Bonnycastle, Lori Ll; Brambilla, Paolo; Burnett, Mary S.; Cesana, Giancarlo; Dimitriou, Maria; Doney, Alex S. F.; Döring, Angela; Muller-Nurasyid, Martina; Elliott, Paul; Chen, Jin; Epstein, Stephen E.; Eyjolfsson, Gudmundur Ingi; Gigante, Bruna; Goodarzi, Mark O.; O’connell, Jeffrey R.; Grallert, Harald; Gravito, Martha L.; Groves, Christopher J.; Hallmans, Göran; Hartikainen, Anna-Liisa; Mueller-Nurasyid, Martina; Hayward, Caroline; Hernandez, Dena; Hicks, Andrew Aa; Müller-Nurasyid, Martina; Holm, Hilma; Hung, Yi-Jen; Illig, Thomas; Jones, Michelle R.; Kaleebu, Pontiano; Kastelein, John J. P.; Khaw, Kay-Tee; Kim, Eric; Klopp, Norman; Komulainen, Pirjo; Mora, Samia; Kumari, Meena; Langenberg, Claudia; Lehtimäki, Terho; Lin, Shih-Yi; Ml, Buchkovich; Lindström, Jaana; Loos, Ruth J. F.; Ingi Eyjolfsson, Gudmundur; Mach, François; McArdle, Wendy L.; Meisinger, Christa; Mitchell, Braxton D.; Müller, Gabrielle; Nagaraja, Ramaiah; Narisu, Narisu; Nieminen, Tuomo V. M.; Nsubuga, Rebecca N.; Olafsson, Isleifur; Ong, Ken Kk; Demirkan, Ayşe; Palotie, Aarno; Papamarkou, Theodore; Pomilla, Cristina; Pouta, Anneli; Doering, Angela; Adair, Linda S.; Arveiler, Dominique; Assimes, Themistocles L.; Bandinelli, Stefania; Bennett, Franklyn; Bochud, Murielle; Muller, Gabrielle; Js, Beckmann; Boehm, Bernhard O.; Mueller, Gabrielle; Boomsma, Dorret I.; Borecki, Ingrid B.; Bornstein, Stefan R.; Bovet, Pascal; Joost van Pelt, L.; Burnier, Michel; Hy, Chang; Campbell, Harry; Do, Ron; Chakravarti, Aravinda; Chambers, John C.; Chen, Yii-Der Ida; Collins, Francis S.; Jl, Bragg Gresham; Cooper, Richard S.; Danesh, John; Dedoussis, George; De Faire, U.; Feranil, Alan B.; Ferrieres, Jean; Ferrucci, Luigi; Freimer, Nelson B.; Gieger, Christian; Groop, Leif C.; Gudnason, Vilmundur; Gyllensten, Ulf; Hamsten, Anders; Harris, Tamara B.; Hingorani, Aroon; Hirschhorn, Joel N.; Hofman, Albert; Hovingh, Gk Kees; Hsiung, Chao Agnes; Kees Hovingh, G.; Humphries, Steve E.; Hunt, Steven C.; Hveem, Kristian; Hm, Den Hertog; Iribarren, Carlos; Järvelin, Marjo-Riitta; Esko, Tõnu; Jula, Antti; Kähönen, Mika; Kaprio, Jaakko; Kesäniemi, Antero; Kivimaki, Mika; Kooner, Jaspal S.; Koudstaal, Peter J.; Krauss, Ronald M.; Kuh, Diana; Kuusisto, Johanna; Kyvik, Kirsten O.; Laakso, Markku; Lakka, Timo A.; Lind, Lars; Lindgren, Cecilia M.; Martin, Nicholas G.; März, Winfried; McCarthy, Mark I.; Mckenzie, Colin A.; Meneton, Pierre; Metspalu, Andres; Moilanen, Leena; Morris, Andrew D.; Munroe, Patricia B.; La, Donnelly; Njølstad, Inger; Jarvelin, Marjo-Riitta; Pedersen, Nancy L.; Power, Chris; Pramstaller, Peter Pp; Kahonen, Mika; März, Winfried; Ordovas, Jose M.; Boerwinkle, Eric; Gb, Ehret; Palmer, Colin N. A.; Price, Jackie F.; Maerz, Winfried; Chasman, Daniel I.; Franks, Paul W.; Cupples, La Adrienne; Adrienne Cupples, L.; Boehnke, Michael; Deloukas, Panos; Kathiresan, Sekar; Mohlke, Karen L.; Ingelsson, Erik; Abecasis, Gonçalo R.

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Carlo Sidore
van Pelt et al., 2013

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@article{van Pelt2013,
  abstract = {Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P &lt; 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.},
  author = {van Pelt, Lj Joost and de Faire, Ulf and van Duijn, Cornelia M. and Willer, Cristen J. and Van den Herik, Evita G. and Service, Susan K. and Shah, Sonia and Shungin, Dmitry and Sidore, Carlo and Song, Ci and WWiller, CJ;Schmidt EM;Sengupta S;Peloso GM;Gustafsson S;Kanoni S;Ganna A;Chen J;Buchkovich ML;Mora S;Beckmann JS;Bragg-Gresham Jl;Chang Hy;Demirkan A;Den Hertog HM;Do R;Donnelly LA;Ehret GB;Esko T;Feitosa MF;Ferreira T;Fischer K;Fontanillas P;Fraser RM;Freitag DF; and Strawbridge, Rona J. and Surakka, Ida and Tanaka, Toshiko and Teslovich, Tanya M. and Thorleifsson, Gudmar and Van Den Herik, E. G. and Voight, Benjamin F. and Volcik, Kelly A. and Waite, Lindsay Ll and Wong, Andrew and Wu, Ying and Zhang, Weihua and Silander, Kaisa and Stančáková, Alena and Stirrups, Kathleen and Swift, Amy J. and Tiret, Laurence and Van Pelt, L. J. and Uitterlinden, Andre G. and Vedantam, Sailaja and Wainwright, Nicholas and Wijmenga, Cisca and Wild, Sarah H. and Willemsen, Gonneke and Wilsgaard, Tom and Wilson, James F. and Young, Elizabeth H. and Zhao, Jing Hua and Sheu, Wayne H.-H. and Shuldiner, Alan R. and Siegbahn, Agneta and Spector, Tim D. and Stefansson, Kari and Strachan, David P. and Tayo, Bamidele O. and Tremoli, Elena and Tuomilehto, Jaakko and Uusitupa, Matti and Van Duijn, C. M. and Vollenweider, Peter and Wallentin, Lars and Wareham, Nicholas J. and Whitfield, John B. and Wolffenbuttel, Bruce H. R. and Thorsteinsdottir, Unnur and Cj, Willer and Schmidt, Ellen M. and Sengupta, Sebanti and Sanna, Serena and Saxena, Richa and Rader, Daniel J. and Reilly, Muredach P. and Ridker, Paul M. and Rivadeneira, Fernando and Rudan, Igor and Ruokonen, Aimo and Samani, Nilesh and Scharnagl, Hubert and Em, Schmidt and Seeley, Janet and Psaty, Bruce M. and Quertermous, Thomas and Rauramaa, Rainer and Saleheen, Danish and Salomaa, Veikko and Sanghera, Dharambir K. and Saramies, Jouko and Schwarz, Peter E. H. and Rotter, Jerome I. and Ripatti, Samuli and Sandhu, Manjinder S. and Rich, Stephen Ss and Consortium, Global Lipids Genetics and Peloso, Gina M. and Johansson, Å. and Buchkovich, Martin L. and Beckmann, Jacques S. and Bragg-Gresham, Jennifer L. and Chang, Hsing-Yi and Den Hertog, Heleen M. and Donnelly, Louise A. and Ehret, Georg B. and Feitosa, Mary F. and Ferreira, Teresa and Fischer, Krista and Fontanillas, Pierre and Fraser, Ross M. and Freitag, Daniel F. and Gm, Peloso and Gurdasani, Deepti and Heikkilä, Kauko and Gustafsson, Stefan and Hyppönen, Elina and Isaacs, Aaron and Jackson, Anne U. and Johnson, Toby and Kaakinen, Marika and Kettunen, Johannes and Kleber, Marcus E. and Li, Xiaohui and Luan, Jian’an and Lyytikäinen, Leo-Pekka and Magnusson, Patrik K. E. and Mangino, Massimo and Kanoni, Stavroula and Mihailov, Evelin and Montasser, May E. and Müller-Nurasyid, Martina and Nolte, Ilja M. and O'Connell, Jeffrey R. and Palmer, Cameron D. and Perola, Markus and Petersen, Ann-Kristin and Johansson, Åsa and Hyppoenen, Elina and Johansson, Åsa and Ganna, Andrea and Absher, Devin and Asiki, Gershim and Barroso, Inês and Been, Latonya F. and Bolton, Jennifer L. and Bonnycastle, Lori Ll and Brambilla, Paolo and Burnett, Mary S. and Cesana, Giancarlo and Dimitriou, Maria and Doney, Alex S. F. and Döring, Angela and Muller-Nurasyid, Martina and Elliott, Paul and Chen, Jin and Epstein, Stephen E. and Eyjolfsson, Gudmundur Ingi and Gigante, Bruna and Goodarzi, Mark O. and O’connell, Jeffrey R. and Grallert, Harald and Gravito, Martha L. and Groves, Christopher J. and Hallmans, Göran and Hartikainen, Anna-Liisa and Mueller-Nurasyid, Martina and Hayward, Caroline and Hernandez, Dena and Hicks, Andrew Aa and Müller-Nurasyid, Martina and Holm, Hilma and Hung, Yi-Jen and Illig, Thomas and Jones, Michelle R. and Kaleebu, Pontiano and Kastelein, John J. P. and Khaw, Kay-Tee and Kim, Eric and Klopp, Norman and Komulainen, Pirjo and Mora, Samia and Kumari, Meena and Langenberg, Claudia and Lehtimäki, Terho and Lin, Shih-Yi and Ml, Buchkovich and Lindström, Jaana and Loos, Ruth J. F. and Ingi Eyjolfsson, Gudmundur and Mach, François and McArdle, Wendy L. and Meisinger, Christa and Mitchell, Braxton D. and Müller, Gabrielle and Nagaraja, Ramaiah and Narisu, Narisu and Nieminen, Tuomo V. M. and Nsubuga, Rebecca N. and Olafsson, Isleifur and Ong, Ken Kk and Demirkan, Ayşe and Palotie, Aarno and Papamarkou, Theodore and Pomilla, Cristina and Pouta, Anneli and Doering, Angela and Adair, Linda S. and Arveiler, Dominique and Assimes, Themistocles L. and Bandinelli, Stefania and Bennett, Franklyn and Bochud, Murielle and Muller, Gabrielle and Js, Beckmann and Boehm, Bernhard O. and Mueller, Gabrielle and Boomsma, Dorret I. and Borecki, Ingrid B. and Bornstein, Stefan R. and Bovet, Pascal and Joost van Pelt, L. and Burnier, Michel and Hy, Chang and Campbell, Harry and Do, Ron and Chakravarti, Aravinda and Chambers, John C. and Chen, Yii-Der Ida and Collins, Francis S. and Jl, Bragg Gresham and Cooper, Richard S. and Danesh, John and Dedoussis, George and De Faire, U. and Feranil, Alan B. and Ferrieres, Jean and Ferrucci, Luigi and Freimer, Nelson B. and Gieger, Christian and Groop, Leif C. and Gudnason, Vilmundur and Gyllensten, Ulf and Hamsten, Anders and Harris, Tamara B. and Hingorani, Aroon and Hirschhorn, Joel N. and Hofman, Albert and Hovingh, Gk Kees and Hsiung, Chao Agnes and Kees Hovingh, G. and Humphries, Steve E. and Hunt, Steven C. and Hveem, Kristian and Hm, Den Hertog and Iribarren, Carlos and Järvelin, Marjo-Riitta and Esko, Tõnu and Jula, Antti and Kähönen, Mika and Kaprio, Jaakko and Kesäniemi, Antero and Kivimaki, Mika and Kooner, Jaspal S. and Koudstaal, Peter J. and Krauss, Ronald M. and Kuh, Diana and Kuusisto, Johanna and Kyvik, Kirsten O. and Laakso, Markku and Lakka, Timo A. and Lind, Lars and Lindgren, Cecilia M. and Martin, Nicholas G. and März, Winfried and McCarthy, Mark I. and Mckenzie, Colin A. and Meneton, Pierre and Metspalu, Andres and Moilanen, Leena and Morris, Andrew D. and Munroe, Patricia B. and La, Donnelly and Njølstad, Inger and Jarvelin, Marjo-Riitta and Pedersen, Nancy L. and Power, Chris and Pramstaller, Peter Pp and Kahonen, Mika and März, Winfried and Ordovas, Jose M. and Boerwinkle, Eric and Gb, Ehret and Palmer, Colin N. A. and Price, Jackie F. and Maerz, Winfried and Chasman, Daniel I. and Franks, Paul W. and Cupples, La Adrienne and Adrienne Cupples, L. and Boehnke, Michael and Deloukas, Panos and Kathiresan, Sekar and Mohlke, Karen L. and Ingelsson, Erik and Abecasis, Gonçalo R.},
  doi = {10.1038/ng.2797},
  month = {oct},
  title = {Discovery and Refinement of Loci Associated with Lipid Levels},
  url = {http://ir.nhri.org.tw/bitstream/3990099045/7633/1/SCP84887099827.pdf},
  year = {2013}
}

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Discovery and Refinement of Loci Associated with Lipid Levels

Journal article published in 2013 by Lj Joost van Pelt, Ulf de Faire, Cornelia M. van Duijn, Cristen J. Willer, Evita G. Van den Herik, Susan K. Service, Sonia Shah, Dmitry Shungin, Carlo Sidore

, Ci Song, CJ;Schmidt EM;Sengupta S;Peloso GM;Gustafsson S;Kanoni S;Ganna A;Chen J;Buchkovich ML;Mora S;Beckmann JS;Bragg-Gresham Jl;Chang Hy;Demirkan A;Den Hertog HM;Do R;Donnelly LA;Ehret GB;Esko T;Feitosa MF;Ferreira T;Fischer K;Fontanillas P;Fraser RM;Freitag DF; WWiller, Rona J. Strawbridge

, Ida Surakka, Toshiko Tanaka, Tanya M. Teslovich and other authors. Lj Joost van Pelt, Ulf de Faire, Cornelia M. van Duijn, Cristen J. Willer, Evita G. Van den Herik, Susan K. Service, Sonia Shah, Dmitry Shungin, Carlo Sidore

, Ida Surakka, Toshiko Tanaka, Tanya M. Teslovich, Gudmar Thorleifsson, E. G. Van Den Herik, Benjamin F. Voight, Kelly A. Volcik, Lindsay Ll Waite, Andrew Wong, Ying Wu, Weihua Zhang, Kaisa Silander, Alena Stančáková, Kathleen Stirrups, Amy J. Swift, Laurence Tiret, L. J. Van Pelt, Andre G. Uitterlinden, Sailaja Vedantam, Nicholas Wainwright, Cisca Wijmenga

, Sarah H. Wild, Gonneke Willemsen, Tom Wilsgaard, James F. Wilson, Elizabeth H. Young, Jing Hua Zhao, Wayne H.-H. Sheu, Alan R. Shuldiner, Agneta Siegbahn, Tim D. Spector, Kari Stefansson, David P. Strachan, Bamidele O. Tayo, Elena Tremoli, Jaakko Tuomilehto, Matti Uusitupa, C. M. Van Duijn, Peter Vollenweider, Lars Wallentin, Nicholas J. Wareham, John B. Whitfield, Bruce H. R. Wolffenbuttel, Unnur Thorsteinsdottir, Willer Cj, Ellen M. Schmidt, Sebanti Sengupta, Serena Sanna

, Richa Saxena, Daniel J. Rader, Muredach P. Reilly, Paul M. Ridker, Fernando Rivadeneira, Igor Rudan, Aimo Ruokonen, Nilesh Samani, Hubert Scharnagl, Schmidt Em, Janet Seeley, Bruce M. Psaty, Thomas Quertermous, Rainer Rauramaa, Danish Saleheen, Veikko Salomaa, Dharambir K. Sanghera, Jouko Saramies, Peter E. H. Schwarz, Jerome I. Rotter, Samuli Ripatti, Manjinder S. Sandhu, Stephen Ss Rich, Global Lipids Genetics Consortium, Gina M. Peloso, Å. Johansson, Martin L. Buchkovich, Jacques S. Beckmann, Jennifer L. Bragg-Gresham, Hsing-Yi Chang, Heleen M. Den Hertog, Louise A. Donnelly, Georg B. Ehret, Mary F. Feitosa, Teresa Ferreira, Krista Fischer, Pierre Fontanillas, Ross M. Fraser, Daniel F. Freitag, Peloso Gm, Deepti Gurdasani

, Kauko Heikkilä, Stefan Gustafsson, Elina Hyppönen

, Aaron Isaacs, Anne U. Jackson, Toby Johnson

, Marika Kaakinen

, Johannes Kettunen, Marcus E. Kleber, Xiaohui Li, Jian’an Luan, Leo-Pekka Lyytikäinen, Patrik K. E. Magnusson, Massimo Mangino, Stavroula Kanoni, Evelin Mihailov, May E. Montasser, Martina Müller-Nurasyid, Ilja M. Nolte, Jeffrey R. O'Connell, Cameron D. Palmer, Markus Perola, Ann-Kristin Petersen, Åsa Johansson, Elina Hyppoenen, Åsa Johansson, Andrea Ganna

, Devin Absher, Gershim Asiki, Inês Barroso, Latonya F. Been, Jennifer L. Bolton, Lori Ll Bonnycastle, Paolo Brambilla, Mary S. Burnett, Giancarlo Cesana, Maria Dimitriou, Alex S. F. Doney, Angela Döring, Martina Muller-Nurasyid, Paul Elliott, Jin Chen, Stephen E. Epstein, Gudmundur Ingi Eyjolfsson, Bruna Gigante

, Mark O. Goodarzi, Jeffrey R. O’connell, Harald Grallert, Martha L. Gravito, Christopher J. Groves, Göran Hallmans, Anna-Liisa Hartikainen, Martina Mueller-Nurasyid, Caroline Hayward, Dena Hernandez, Andrew Aa Hicks, Martina Müller-Nurasyid, Hilma Holm, Yi-Jen Hung, Thomas Illig, Michelle R. Jones, Pontiano Kaleebu, John J. P. Kastelein, Kay-Tee Khaw, Eric Kim, Norman Klopp, Pirjo Komulainen, Samia Mora, Meena Kumari, Claudia Langenberg, Terho Lehtimäki, Shih-Yi Lin, Buchkovich Ml, Jaana Lindström, Ruth J. F. Loos, Gudmundur Ingi Eyjolfsson, François Mach, Wendy L. McArdle, Christa Meisinger

, Braxton D. Mitchell, Gabrielle Müller, Ramaiah Nagaraja, Narisu Narisu, Tuomo V. M. Nieminen, Rebecca N. Nsubuga, Isleifur Olafsson, Ken Kk Ong, Ayşe Demirkan, Aarno Palotie, Theodore Papamarkou, Cristina Pomilla, Anneli Pouta, Angela Doering, Linda S. Adair, Dominique Arveiler, Themistocles L. Assimes, Stefania Bandinelli, Franklyn Bennett, Murielle Bochud, Gabrielle Muller, Beckmann Js, Bernhard O. Boehm, Gabrielle Mueller, Dorret I. Boomsma, Ingrid B. Borecki, Stefan R. Bornstein, Pascal Bovet

, L. Joost van Pelt, Michel Burnier, Chang Hy, Harry Campbell, Ron Do, Aravinda Chakravarti, John C. Chambers, Yii-Der Ida Chen, Francis S. Collins, Bragg Gresham Jl, Richard S. Cooper, John Danesh, George Dedoussis, U. De Faire, Alan B. Feranil, Jean Ferrieres, Luigi Ferrucci, Nelson B. Freimer, Christian Gieger

, Leif C. Groop, Vilmundur Gudnason, Ulf Gyllensten, Anders Hamsten, Tamara B. Harris, Aroon Hingorani, Joel N. Hirschhorn, Albert Hofman, Gk Kees Hovingh, Chao Agnes Hsiung, G. Kees Hovingh, Steve E. Humphries, Steven C. Hunt, Kristian Hveem, Den Hertog Hm, Carlos Iribarren, Marjo-Riitta Järvelin, Tõnu Esko

, Antti Jula, Mika Kähönen, Jaakko Kaprio, Antero Kesäniemi, Mika Kivimaki

, Jaspal S. Kooner, Peter J. Koudstaal, Ronald M. Krauss, Diana Kuh, Johanna Kuusisto, Kirsten O. Kyvik, Markku Laakso, Timo A. Lakka, Lars Lind, Cecilia M. Lindgren, Nicholas G. Martin

, Winfried März, Mark I. McCarthy, Colin A. Mckenzie, Pierre Meneton, Andres Metspalu, Leena Moilanen, Andrew D. Morris, Patricia B. Munroe, Donnelly La, Inger Njølstad, Marjo-Riitta Jarvelin, Nancy L. Pedersen, Chris Power, Peter Pp Pramstaller

, Mika Kahonen, Winfried März, Jose M. Ordovas, Eric Boerwinkle, Ehret Gb, Colin N. A. Palmer, Jackie F. Price

, Winfried Maerz, Daniel I. Chasman, Paul W. Franks, La Adrienne Cupples, L. Adrienne Cupples, Michael Boehnke, Panos Deloukas, Sekar Kathiresan, Karen L. Mohlke, Erik Ingelsson, Gonçalo R. Abecasis

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Abstract

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

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Discovery and Refinement of Loci Associated with Lipid Levels

Abstract