Published in
Oxford University Press (OUP), Human Molecular Genetics, 9(23), p. 2490-2497
DOI: 10.1093/hmg/ddt620
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DNA mismatch repair gene MSH6 implicated in determining age at natural menopause
Journal article published in 2013 by
Adamo Pio d’Adamo,
Hsu Yh,
John Rb B. Perry,
Yi-Hsiang Hsu,
Daniel I. Chasman,
Perry Jr,
Andrew D. Johnson,
Bojesen Se,
Cathy Elks,
Eva Albrecht,
Chasman Di,
Irene L. Andrulis,
Stig E. Bojesen,
Jonathan Beesley 
,
Johnson Ad
and other authors.
,
Johnson Ad
and other authors.
This paper is made freely available by the publisher.
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Abstract
The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known to contribute to ∼50% of the variation in both age at menarche and menopause, but to date the known genes explain