Dissemin is shutting down on January 1st, 2025

Published in

Nature Research, Nature Genetics, 4(45), p. 428-432, 2013

DOI: 10.1038/ng.2571

Links

Tools

Export citation

Search in Google Scholar

A variant in FTO shows association with melanoma risk not due to BMI

Journal article published in 2013 by Simon N. Stacey, Mark Mm Iles, John C. Taylor, Anne C. de Waal, Anne C. de Waal, N. van der Stoep, N. Van Der Stoep, M. M. Van Rossum, D. Timothy Bishop, M. E. L. C. Geno, Matthew H. Law, Shenying Fang, Aben Kk, Cust Ae, Katja K. H. Aben and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 x 10(-12), per-allele odds ratio for allele A = 1.16). In addition to identifying a new melanoma-susceptibility locus, this is to our knowledge the first study to identify and replicate an association with SNPs in FTO not related to body mass index (BMI). These SNPs are not in intron 1 (the BMI-related region) and exhibit no association with BMI. This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity.