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Nature Research, Nature Genetics, 3(40), p. 281-283, 2008

DOI: 10.1038/ng.89

Elsevier, Urologic Oncology: Seminars and Original Investigations, 5(26), p. 569-570

DOI: 10.1016/j.urolonc.2008.07.012

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Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer

Journal article published in 2008 by Julius Gudmundsson, Patrick Sulem, Thorunn Rafnar, Jon T. Bergthorsson, Andrei Manolescu, Daniel Gudbjartsson ORCID, S. Lilly Zheng, Bjarni A. Agnarsson, Asgeir Sigurdsson, Kristrun R. Benediktsdottir, Thorarinn Blondal, Margret Jakobsdottir, Simon N. Stacey, Jelena Kostic, Kari T. Kristinsson and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.