Nature Research, Nature Genetics, 3(40), p. 281-283, 2008
DOI: 10.1038/ng.89
Elsevier, Urologic Oncology: Seminars and Original Investigations, 5(26), p. 569-570
DOI: 10.1016/j.urolonc.2008.07.012
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We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.