Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Stolk, Lisette; Jr, Perry; Jrb, Perry; Perry, John R. B.; Di, Chasman; Chasman, Daniel I.; He, Chunyan; Cy, He; Mangino, Massimo; Sulem, Patrick; Barbalic, Maja; Em, Byrne; Broer, Linda; Byrne, Enda M.; Ernst, Florian; Df, Gudbjartsson; Esko, Tonu; Franceschini, Nora; Jj, Hottenga; Gudbjartsson, Daniel F.; Pf, McArdle; Hottenga, Jouke-Jan; Kraft, Peter; Sy, Shin; McArdle, Patrick F.; Av, Smith; Porcu, Eleonora; Wv, Zhuang; Shin, So-Youn; Smith, Albert V.; Bz, Alizadeh; van Wingerden, Sophie; Van Wingerden, S.; Zhai, Guangju; Zhuang, Wei V.; Lb, Lauc; Albrecht, Eva; Alizadeh, Behrooz Z.; Js, Beckmann; Aspelund, Thor; Barac Lauc, Lovorka; Bandinelli, Stefania; Fj, Broekmans; Lauc, Lovorka Barac; Beckmann, Jacques S.; Sj, Chanock; Boban, Mladen; Boerwinkle, Eric; Mc, Cornelis; Broekmans, Frank J.; Ad, Coviello; Burri, Andrea; Campbell, Harry; Ej, de Geus; Chanock, Stephen J.; Gv, Dedoussis; Chen, Constance; Cornelis, Marilyn C.; D'Adamo, Adamo Pio; Corre, Tanguy; Ij, Deary; Coviello, Andrea D.; d'Adamo, Pio; De Faire, U.; Davies, Gail; De Geus, E. J. C.; de Faire, Ulf; de Geus, Eco J. C.; Ejc, de Geus; Deary, Ian J.; Gvz, Dedoussis; Dedoussis, George V. Z.; Bc, Fauser; Deloukas, Panagiotis; Ebrahim, Shah; Jg, Eriksson; Eiriksdottir, Gudny; Bcjm, Fauser; Emilsson, Valur; Eriksson, Johan G.; Ar, Folsom; Fauser, Bart C. J. M.; Ferreli, Liana; Me, Garcia; Ferrucci, Luigi; De, Grobbee; Fischer, Krista; Folsom, Aaron R.; Ac, Janssens; Garcia, Melissa E.; Se, Hankinson; Gasparini, Paolo; Ac, Heath; Gieger, Christian; Glazer, Nicole; Sl, Kardia; Grobbee, Diederick E.; Hall, Per; Ad, Johnson; Haller, Toomas; Cecile J. W. Janssens, A.; Hankinson, Susan E.; Hass, Merli; Js, Laven; Hayward, Caroline; Acjw, Janssens; Heath, Andrew C.; Hofman, Albert; Dp, Kiel; Ingelsson, Erik; Slr, Kardia; Janssens, Acjw Cecile J. W.; Johnson, Andrew D.; Pk, Magnusson; Karasik, David; Da, Lawlor; Kardia, Sharon L. R.; Keyzer, Jules; Lm, Lopez; Kiel, Douglas P.; Yv, Louwers; Kolcic, Ivana; E. Laven, Joop S.; Kutalik, Zoltan; Lahti, Jari; Jse, Laven; Lai, Sandra; Ng, Martin; Laisk, Triin; Laven, Joop S. E.; Jj, Liu; Lawlor, Debbie A.; Im, Klaric; Liu, Jianjun; Lopez, Lorna M.; Pke, Magnusson; Louwers, Yvonne V.; Se, Medland; Magnusson, Patrik K. E.; Marongiu, Mara; Martinović Klarić, Irena; Martin, Nicholas G.; Ab, Newman; Klaric, Irena Martinovic; Masciullo, Corrado; Dr, Nyholt; McKnight, Barbara; Charlotte Onland Moret, N.; Medland, Sarah E.; Melzer, David; Nc, Onland Moret; Mooser, Vincent; Ph, Peeters; Navarro, Pau; Newman, Anne B.; An, Parker; Nyholt, Dale R.; Onland-Moret, Nc Charlotte; Pare, Guillaume; Palotie, Aarno; Nl, Pedersen; Paré, Guillaume; Parker, Alex N.; Vj, Pop; Pedersen, Nancy L.; As, Plump; Peeters, Petra H. M.; Phm, Peeters; Pistis, Giorgio; Plump, Andrew S.; Bm, Psaty; Polasek, Ozren; Currency Signikkonen K., R.; Pop, Victor J. M.; Psaty, Bruce M.; Vjm, Pop; Räikkönen, Katri; Raikkonen, Katri; Rehnberg, Emil; Rotter, Jerome I.; Ji, Rotter; Rudan, Igor; Ja, Smith; Sala, Cinzia; Salumets, Andres; Sn, Stacey; Scuteri, Angelo; Jm, Starr; Singleton, Andrew; Smith, Jennifer A.; Mg, Stathopoulou; Snieder, Harold; Rp, Stolk; Soranzo, Nicole; Stacey, Simon N.; Yv, Sun; Starr, John M.; Rm, van Dam; Stathopoulou, Maria G.; Stirrups, Kathleen; Van Dam, R. M.; Stolk, Ronald P.; Styrkarsdottir, Unnur; Van Der Schouw, Y. T.; Sun, Yan V.; Yt, van der Schouw; Tenesa, Albert; Ch, van Gils; Thorand, Barbara; Toniolo, Daniela; Van Gils, C. H.; Tryggvadottir, Laufey; Tsui, Kim; Van Nierop, P.; Ulivi, Sheila; He, Wichmann; van Dam, Rob M.; Jm, Vink; van der Schouw, Yvonne T.; van Gils, Carla H.; Pm, Visscher; van Nierop, Peter; Vink, Jacqueline M.; Cj, Wijnands van Gent; Visscher, Peter M.; Erich Wichmann, H.; Voorhuis, Marlies; Bh, Wolffenbuttel; Waeber, Gerard; Wallaschofski, Henri; Jf, Wilson; Wichmann, He Erich; Cjm, Wijnands van Gent; Widen, Elisabeth; Wijnands-Van Gent, Colette J. M.; Af, Wright; Willemsen, Gonneke; Lm, Yerges Armstrong; Wilson, James F.; Wolffenbuttel, Bruce H. R.; Tl, Study; Wright, Alan F.; Bhr, Wolffenbuttel; Yerges-Armstrong, Laura M.; Mc, Zillikens; Zemunik, Tatijana; Zgaga, Lina; Carola Zillikens, M.; Zillikens, Mc Carola; Am, Arnold; Zygmunt, Marek; Study, The LifeLines Cohort; Di, Boomsma; Arnold, Alice M.; Boomsma, Dorret I.; Je, Buring; Buring, Julie E.; Ew, Demerath; Crisponi, Laura; Demerath, Ellen W.; Tb, Harris; Gudnason, Vilmundur; Fb, Hu; Harris, Tamara B.; Hu, Frank B.; Dj, Hunter; Hunter, David J.; Lj, Launer; Launer, Lenore J.; Metspalu, Andres; Gw, Montgomery; Montgomery, Grant W.; Ba, Oostra; Oostra, Ben A.; Pm, Ridker; Ridker, Paul M.; Sanna, Serena; Schlessinger, David; Td, Spector; Spector, Tim D.; Ea, Streeten; Stefansson, Kari; Ag, Uitterlinden; Streeten, Elizabeth A.; Thorsteinsdottir, Unnur; Van Duijn, C. M.; Uda, Manuela; Uitterlinden, Andre G.; Voelzke, Henry; van Duijn, Cornelia M.; Cm, van Duijn; Völzke, Henry; Volzke, H.; Murray, Anna; Jm, Murabito; Murabito, Joanne M.; Ja, Visser; Visser, Jenny A.; Kl, Lunetta; Lunetta, Kathryn L.

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Linda Broer
Stolk et al., 2012

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Nature Research, Nature Genetics, 3(44), p. 260-268

DOI: 10.1038/ng.1051

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@article{Stolk2012,
  abstract = {To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P &lt; 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.},
  author = {Stolk, Lisette and Jr, Perry and Jrb, Perry and Perry, John R. B. and Di, Chasman and Chasman, Daniel I. and He, Chunyan and Cy, He and Mangino, Massimo and Sulem, Patrick and Barbalic, Maja and Em, Byrne and Broer, Linda and Byrne, Enda M. and Ernst, Florian and Df, Gudbjartsson and Esko, Tonu and Franceschini, Nora and Jj, Hottenga and Gudbjartsson, Daniel F. and Pf, McArdle and Hottenga, Jouke-Jan and Kraft, Peter and Sy, Shin and McArdle, Patrick F. and Av, Smith and Porcu, Eleonora and Wv, Zhuang and Shin, So-Youn and Smith, Albert V. and Bz, Alizadeh and van Wingerden, Sophie and Van Wingerden, S. and Zhai, Guangju and Zhuang, Wei V. and Lb, Lauc and Albrecht, Eva and Alizadeh, Behrooz Z. and Js, Beckmann and Aspelund, Thor and Barac Lauc, Lovorka and Bandinelli, Stefania and Fj, Broekmans and Lauc, Lovorka Barac and Beckmann, Jacques S. and Sj, Chanock and Boban, Mladen and Boerwinkle, Eric and Mc, Cornelis and Broekmans, Frank J. and Ad, Coviello and Burri, Andrea and Campbell, Harry and Ej, de Geus and Chanock, Stephen J. and Gv, Dedoussis and Chen, Constance and Cornelis, Marilyn C. and D'Adamo, Adamo Pio and Corre, Tanguy and Ij, Deary and Coviello, Andrea D. and d'Adamo, Pio and De Faire, U. and Davies, Gail and De Geus, E. J. C. and de Faire, Ulf and de Geus, Eco J. C. and Ejc, de Geus and Deary, Ian J. and Gvz, Dedoussis and Dedoussis, George V. Z. and Bc, Fauser and Deloukas, Panagiotis and Ebrahim, Shah and Jg, Eriksson and Eiriksdottir, Gudny and Bcjm, Fauser and Emilsson, Valur and Eriksson, Johan G. and Ar, Folsom and Fauser, Bart C. J. M. and Ferreli, Liana and Me, Garcia and Ferrucci, Luigi and De, Grobbee and Fischer, Krista and Folsom, Aaron R. and Ac, Janssens and Garcia, Melissa E. and Se, Hankinson and Gasparini, Paolo and Ac, Heath and Gieger, Christian and Glazer, Nicole and Sl, Kardia and Grobbee, Diederick E. and Hall, Per and Ad, Johnson and Haller, Toomas and Cecile J. W. Janssens, A. and Hankinson, Susan E. and Hass, Merli and Js, Laven and Hayward, Caroline and Acjw, Janssens and Heath, Andrew C. and Hofman, Albert and Dp, Kiel and Ingelsson, Erik and Slr, Kardia and Janssens, Acjw Cecile J. W. and Johnson, Andrew D. and Pk, Magnusson and Karasik, David and Da, Lawlor and Kardia, Sharon L. R. and Keyzer, Jules and Lm, Lopez and Kiel, Douglas P. and Yv, Louwers and Kolcic, Ivana and E. Laven, Joop S. and Kutalik, Zoltan and Lahti, Jari and Jse, Laven and Lai, Sandra and Ng, Martin and Laisk, Triin and Laven, Joop S. E. and Jj, Liu and Lawlor, Debbie A. and Im, Klaric and Liu, Jianjun and Lopez, Lorna M. and Pke, Magnusson and Louwers, Yvonne V. and Se, Medland and Magnusson, Patrik K. E. and Marongiu, Mara and Martinović Klarić, Irena and Martin, Nicholas G. and Ab, Newman and Klaric, Irena Martinovic and Masciullo, Corrado and Dr, Nyholt and McKnight, Barbara and Charlotte Onland Moret, N. and Medland, Sarah E. and Melzer, David and Nc, Onland Moret and Mooser, Vincent and Ph, Peeters and Navarro, Pau and Newman, Anne B. and An, Parker and Nyholt, Dale R. and Onland-Moret, Nc Charlotte and Pare, Guillaume and Palotie, Aarno and Nl, Pedersen and Paré, Guillaume and Parker, Alex N. and Vj, Pop and Pedersen, Nancy L. and As, Plump and Peeters, Petra H. M. and Phm, Peeters and Pistis, Giorgio and Plump, Andrew S. and Bm, Psaty and Polasek, Ozren and Currency Signikkonen K., R. and Pop, Victor J. M. and Psaty, Bruce M. and Vjm, Pop and Räikkönen, Katri and Raikkonen, Katri and Rehnberg, Emil and Rotter, Jerome I. and Ji, Rotter and Rudan, Igor and Ja, Smith and Sala, Cinzia and Salumets, Andres and Sn, Stacey and Scuteri, Angelo and Jm, Starr and Singleton, Andrew and Smith, Jennifer A. and Mg, Stathopoulou and Snieder, Harold and Rp, Stolk and Soranzo, Nicole and Stacey, Simon N. and Yv, Sun and Starr, John M. and Rm, van Dam and Stathopoulou, Maria G. and Stirrups, Kathleen and Van Dam, R. M. and Stolk, Ronald P. and Styrkarsdottir, Unnur and Van Der Schouw, Y. T. and Sun, Yan V. and Yt, van der Schouw and Tenesa, Albert and Ch, van Gils and Thorand, Barbara and Toniolo, Daniela and Van Gils, C. H. and Tryggvadottir, Laufey and Tsui, Kim and Van Nierop, P. and Ulivi, Sheila and He, Wichmann and van Dam, Rob M. and Jm, Vink and van der Schouw, Yvonne T. and van Gils, Carla H. and Pm, Visscher and van Nierop, Peter and Vink, Jacqueline M. and Cj, Wijnands van Gent and Visscher, Peter M. and Erich Wichmann, H. and Voorhuis, Marlies and Bh, Wolffenbuttel and Waeber, Gerard and Wallaschofski, Henri and Jf, Wilson and Wichmann, He Erich and Cjm, Wijnands van Gent and Widen, Elisabeth and Wijnands-Van Gent, Colette J. M. and Af, Wright and Willemsen, Gonneke and Lm, Yerges Armstrong and Wilson, James F. and Wolffenbuttel, Bruce H. R. and Tl, Study and Wright, Alan F. and Bhr, Wolffenbuttel and Yerges-Armstrong, Laura M. and Mc, Zillikens and Zemunik, Tatijana and Zgaga, Lina and Carola Zillikens, M. and Zillikens, Mc Carola and Am, Arnold and Zygmunt, Marek and Study, The LifeLines Cohort and Di, Boomsma and Arnold, Alice M. and Boomsma, Dorret I. and Je, Buring and Buring, Julie E. and Ew, Demerath and Crisponi, Laura and Demerath, Ellen W. and Tb, Harris and Gudnason, Vilmundur and Fb, Hu and Harris, Tamara B. and Hu, Frank B. and Dj, Hunter and Hunter, David J. and Lj, Launer and Launer, Lenore J. and Metspalu, Andres and Gw, Montgomery and Montgomery, Grant W. and Ba, Oostra and Oostra, Ben A. and Pm, Ridker and Ridker, Paul M. and Sanna, Serena and Schlessinger, David and Td, Spector and Spector, Tim D. and Ea, Streeten and Stefansson, Kari and Ag, Uitterlinden and Streeten, Elizabeth A. and Thorsteinsdottir, Unnur and Van Duijn, C. M. and Uda, Manuela and Uitterlinden, Andre G. and Voelzke, Henry and van Duijn, Cornelia M. and Cm, van Duijn and Völzke, Henry and Volzke, H. and Murray, Anna and Jm, Murabito and Murabito, Joanne M. and Ja, Visser and Visser, Jenny A. and Kl, Lunetta and Lunetta, Kathryn L.},
  doi = {10.1038/ng.1051},
  journal = {Nature Genetics},
  month = {jan},
  pages = {260-268},
  title = {Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways},
  url = {http://idiprints.knjiznica.idi.hr/237/},
  volume = {44},
  year = {2012}
}

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Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Journal article published in 2012 by Lisette Stolk, Perry Jr, Perry Jrb, John R. B. Perry, Chasman Di, Daniel I. Chasman, Chunyan He, He Cy, Massimo Mangino, Patrick Sulem, Maja Barbalic, Byrne Em, Linda Broer

, Enda M. Byrne, Florian Ernst and other authors. Lisette Stolk, Perry Jr, Perry Jrb, John R. B. Perry, Chasman Di, Daniel I. Chasman, Chunyan He, He Cy, Massimo Mangino, Patrick Sulem, Maja Barbalic, Byrne Em, Linda Broer

, Enda M. Byrne, Florian Ernst, Gudbjartsson Df, Tonu Esko

, Nora Franceschini, Hottenga Jj, Daniel F. Gudbjartsson

, McArdle Pf, Jouke-Jan Hottenga, Peter Kraft, Shin Sy, Patrick F. McArdle, Smith Av, Eleonora Porcu, Zhuang Wv, So-Youn Shin, Albert V. Smith

, Alizadeh Bz, Sophie van Wingerden, S. Van Wingerden, Guangju Zhai, Wei V. Zhuang, Lauc Lb, Eva Albrecht, Behrooz Z. Alizadeh, Beckmann Js, Thor Aspelund, Lovorka Barac Lauc, Stefania Bandinelli, Broekmans Fj, Lovorka Barac Lauc, Jacques S. Beckmann

, Chanock Sj, Mladen Boban, Eric Boerwinkle, Cornelis Mc, Frank J. Broekmans, Coviello Ad, Andrea Burri, Harry Campbell, de Geus Ej, Stephen J. Chanock, Dedoussis Gv, Constance Chen, Marilyn C. Cornelis, Adamo Pio D'Adamo

, Tanguy Corre, Deary Ij, Andrea D. Coviello, Pio d'Adamo, U. De Faire, Gail Davies, E. J. C. De Geus, Ulf de Faire, Eco J. C. de Geus, de Geus Ejc, Ian J. Deary, Dedoussis Gvz, George V. Z. Dedoussis, Fauser Bc, Panagiotis Deloukas

, Shah Ebrahim, Eriksson Jg, Gudny Eiriksdottir, Fauser Bcjm, Valur Emilsson, Johan G. Eriksson, Folsom Ar, Bart C. J. M. Fauser, Liana Ferreli, Garcia Me, Luigi Ferrucci, Grobbee De, Krista Fischer, Aaron R. Folsom, Janssens Ac, Melissa E. Garcia, Hankinson Se, Paolo Gasparini, Heath Ac, Christian Gieger

, Nicole Glazer, Kardia Sl, Diederick E. Grobbee, Per Hall, Johnson Ad, Toomas Haller, A. Cecile J. W. Janssens, Susan E. Hankinson, Merli Hass, Laven Js, Caroline Hayward, Janssens Acjw, Andrew C. Heath, Albert Hofman, Kiel Dp, Erik Ingelsson, Kardia Slr, Acjw Cecile J. W. Janssens

, Andrew D. Johnson, Magnusson Pk, David Karasik, Lawlor Da, Sharon L. R. Kardia, Jules Keyzer, Lopez Lm, Douglas P. Kiel

, Louwers Yv, Ivana Kolcic, Joop S. E. Laven, Zoltan Kutalik, Jari Lahti

, Laven Jse, Sandra Lai, Martin Ng, Triin Laisk

, Joop S. E. Laven, Liu Jj, Debbie A. Lawlor, Klaric Im, Jianjun Liu, Lorna M. Lopez, Magnusson Pke, Yvonne V. Louwers, Medland Se, Patrik K. E. Magnusson, Mara Marongiu, Irena Martinović Klarić, Nicholas G. Martin

, Newman Ab, Irena Martinovic Klaric, Corrado Masciullo, Nyholt Dr, Barbara McKnight, N. Charlotte Onland Moret, Sarah E. Medland, David Melzer

, Onland Moret Nc, Vincent Mooser, Peeters Ph, Pau Navarro, Anne B. Newman

, Parker An, Dale R. Nyholt

, Nc Charlotte Onland-Moret, Guillaume Pare, Aarno Palotie, Pedersen Nl, Guillaume Paré, Alex N. Parker, Pop Vj, Nancy L. Pedersen, Plump As, Petra H. M. Peeters, Peeters Phm, Giorgio Pistis, Andrew S. Plump, Psaty Bm, Ozren Polasek, R. Currency Signikkonen K., Victor J. M. Pop, Bruce M. Psaty, Pop Vjm, Katri Räikkönen, Katri Raikkonen, Emil Rehnberg, Jerome I. Rotter, Rotter Ji, Igor Rudan, Smith Ja, Cinzia Sala, Andres Salumets, Stacey Sn, Angelo Scuteri, Starr Jm, Andrew Singleton, Jennifer A. Smith

, Stathopoulou Mg, Harold Snieder, Stolk Rp, Nicole Soranzo, Simon N. Stacey, Sun Yv, John M. Starr, van Dam Rm, Maria G. Stathopoulou, Kathleen Stirrups, R. M. Van Dam, Ronald P. Stolk, Unnur Styrkarsdottir, Y. T. Van Der Schouw, Yan V. Sun, van der Schouw Yt, Albert Tenesa, van Gils Ch, Barbara Thorand, Daniela Toniolo, C. H. Van Gils, Laufey Tryggvadottir, Kim Tsui, P. Van Nierop, Sheila Ulivi, Wichmann He, Rob M. van Dam, Vink Jm, Yvonne T. van der Schouw

, Carla H. van Gils, Visscher Pm, Peter van Nierop, Jacqueline M. Vink, Wijnands van Gent Cj, Peter M. Visscher, H. Erich Wichmann, Marlies Voorhuis, Wolffenbuttel Bh, Gerard Waeber, Henri Wallaschofski, Wilson Jf, He Erich Wichmann, Wijnands van Gent Cjm, Elisabeth Widen, Colette J. M. Wijnands-Van Gent, Wright Af, Gonneke Willemsen, Yerges Armstrong Lm, James F. Wilson, Bruce H. R. Wolffenbuttel, Study Tl, Alan F. Wright, Wolffenbuttel Bhr, Laura M. Yerges-Armstrong, Zillikens Mc, Tatijana Zemunik, Lina Zgaga, M. Carola Zillikens, Mc Carola Zillikens, Arnold Am, Marek Zygmunt, The LifeLines Cohort Study, Boomsma Di, Alice M. Arnold, Dorret I. Boomsma, Buring Je, Julie E. Buring, Demerath Ew, Laura Crisponi, Ellen W. Demerath, Harris Tb, Vilmundur Gudnason, Hu Fb, Tamara B. Harris, Frank B. Hu, Hunter Dj, David J. Hunter, Launer Lj, Lenore J. Launer, Andres Metspalu, Montgomery Gw, Grant W. Montgomery, Oostra Ba, Ben A. Oostra, Ridker Pm, Paul M. Ridker, Serena Sanna

, David Schlessinger, Spector Td, Tim D. Spector, Streeten Ea, Kari Stefansson, Uitterlinden Ag, Elizabeth A. Streeten, Unnur Thorsteinsdottir, C. M. Van Duijn, Manuela Uda, Andre G. Uitterlinden, Henry Voelzke, Cornelia M. van Duijn, van Duijn Cm, Henry Völzke, H. Volzke, Anna Murray, Murabito Jm, Joanne M. Murabito, Visser Ja, Jenny A. Visser, Lunetta Kl, Kathryn L. Lunetta

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Abstract

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.

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Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Abstract