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Nature Research, Nature Genetics, 6(40), p. 703-706, 2008

DOI: 10.1038/ng.131

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Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer

Journal article published in 2008 by Simon N. Stacey, Andrei Manolescu, Patrick Sulem, Steinunn Thorlacius, Sigurjon A. Gudjonsson ORCID, Gudbjorn F. Jonsson, Margret Jakobsdottir, Jon T. Bergthorsson, Julius Gudmundsson, Katja K. H. Aben ORCID, Luc J. Strobbe, Dorine W. Swinkels, K. C. Anton van Engelenburg, K. C. Anton van Engelenburg, K. C. A. van Engelenburg and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We carried out a genome-wide association study of breast cancer predisposition with replication and refinement studies involving 6,145 cases and 33,016 controls and identified two SNPs (rs4415084 and rs10941679) on 5p12 that confer risk, preferentially for estrogen receptor (ER)-positive tumors (OR = 1.27, P = 2.5 x 10(-12) for rs10941679). The nearest gene, MRPS30, was previously implicated in apoptosis, ER-positive tumors and favorable prognosis. A recently reported signal in FGFR2 was also found to associate specifically with ER-positive breast cancer.