Published in
Nature Research, Nature Genetics, 10(41), p. 1122-1126, 2009
DOI: 10.1038/ng.448
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- [www.ncbi.nlm.nih.gov] | PDF
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- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility
,
Thorarinn Blondal,
Arnaldur Gylfason,
Bjarni A. Agnarsson,
Kristrun R. Benediktsdottir,
Droplaug N. Magnusdottir,
Gudbjorg Orlygsdottir,
Margret Jakobsdottir,
Simon N. Stacey,
Asgeir Sigurdsson,
Tiina Wahlfors,
Teuvo Tammela,
Joan P. Breyer
and other authors.
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Abstract
We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 x 10(-11)) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 x 10(-12)). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population.