Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Kilpeläinen, Tuomas O.; Zillikens, Mc Carola; To, KilpelÃ¤inen; Mc, Zillikens; Stančáková, Alena; Stanč;Ã¡kova, A.; Finucane, Francis M.; Fm, Finucane; Ried, Janina S.; Js, Ried; Langenberg, Claudia; Zhang, Weihua; Beckmann, Jacques S.; Js, Beckmann; Luan, Jian’an; Vandenput, Liesbeth; Styrkársdóttir, Unnur; Zhou, Yanhua; Smith, Albert Vernon; Av, Smith; Zhao, Jing-Hua; Jh, Zhao; Amin, Najaf; Vedantam, Sailaja; Shin, So-Youn; Sy, Shin; Haritunians, Talin; Fu, Mao; Feitosa, Mary F.; Mf, Feitosa; Kumari, Meena; Bv, Halldorsson; Halldorsson, Bjarni V.; Tikkanen, Emmi; Am, Arnold; Mangino, Massimo; Hayward, Caroline; Ys, Aulchenko; Song, Ci; Arnold, Alice M.; Ba, Oostra; Aulchenko, Yurii S.; Oostra, Ben A.; La, Cupples; Campbell, Harry; Cupples, La Adrienne; Ke, Davis; Davis, Kathryn E.; Döring, Angela; Doring, Angela; DÃ¶ring, A.; Eiriksdottir, Gudny; Estrada, Karol; Fernández-Real, José Manuel; Jm, FernÃ¡ndez Real; Garcia, Melissa; Gieger, Christian; Nl, Glazer; Glazer, Nicole L.; Guiducci, Candace; Se, Humphries; Hofman, Albert; Humphries, Steve E.; Lc, Jacobs; Isomaa, Bo; Mk, Karlsson; Jacobs, Leonie C.; Jula, Antti; Kt, Khaw; Karasik, David; Karlsson, Magnus K.; Lj, Kim; Khaw, Kay-Tee; Kim, Lauren J.; KivimÃ¤ki, M.; Kivimaki, Mika; Klopp, Norman; KÃ½hnel, B.; Kühnel, Brigitte; Kuhnel, B.; Kuusisto, Johanna; Ljunggren, Östen; Liu, Yongmei; Ljunggren, Osten; Lorentzon, Mattias; Rn, Luben; Luben, Robert N.; Mcknight, Barbara; MellstrÃ¶m, D.; Mellström, Dan; Mitchell, Braxton D.; Bd, Mitchell; Mooser, Vincent; Moreno, José Maria; Jm, Moreno; Männistö, Satu; Männistö, Satu; O'Connell, Jeffery R.; S., MÃ¤nnistÃ¶; O’Connell, Jeffery R.; Pascoe, Laura; Peltonen, Leena; Peral, Belén; Perola, Markus; Bm, Psaty; Psaty, Bruce M.; Salomaa, Veikko; Db, Savage; Savage, David B.; Rk, Semple; Semple, Robert K.; Skaric-Juric, Tatjana; Sigurðsson, Gunnar; Ks, Song; Song, Kijoung S.; Td, Spector; Spector, Timothy D.; Ac, SyvÃ¤nen; Syvanen, Ann-Christine; Talmud, Philippa J.; Pj, Talmud; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Uitterlinden, Andre G.; van Duijn, Cornelia M.; Ag, Uitterlinden; Cm, van Duijn; Vidal-Puig, Antonio; Wild, Sarah H.; Sh, Wild; Wright, Alan F.; Af, Wright; Clegg, Deborah J.; Dj, Clegg; Schadt, Eric; Wilson, James F.; Jf, Wilson; Rudan, Igor; Ripatti, Samuli; Borecki, Ingrid B.; Ib, Borecki; Shuldiner, Alan R.; Ar, Shuldiner; Ingelsson, Erik; Jansson, John-Olov; Jo, Jansson; Kaplan, Robert C.; Rc, Kaplan; Gudnason, Vilmundur; Harris, Tamara B.; Tb, Harris; Groop, Leif; Kiel, Douglas P.; Dp, Kiel; Rivadeneira, Fernando; Walker, Mark; Barroso, Inês; Vollenweider, Peter; Waeber, Gerard; Jc, Chambers; Chambers, John C.; Kooner, Jaspal S.; Js, Kooner; Soranzo, Nicole; Jn, Hirschhorn; Hirschhorn, Joel N.; Stefansson, Kari; He, Wichmann; Wichmann, He-Erich; Ohlsson, Claes; O’Rahilly, Stephen; O'Rahilly, Stephen; Nj, Wareham; Wareham, Nicholas J.; Ek, Speliotes; Speliotes, Elizabeth K.; Cs, Fox; Fox, Caroline S.; Laakso, Markku; Loos, Ruth J. F.; Rj, Loos

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Jacques S. Beckmann
Kilpeläinen et al., 2011

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Nature Research, Nature Genetics, 8(43), p. 753-760

DOI: 10.1038/ng.866

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@article{Kilpeläinen2011,
  abstract = {Genome-wide association studies have identified 32 loci associated with body mass index (BMI), a measure that does not allow distinguishing lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ~2.5 million SNPs and body fat percentage from 36,626 individuals, and followed up the 14 most significant (P},
  author = {Kilpeläinen, Tuomas O. and Zillikens, Mc Carola and To, KilpelÃ¤inen and Mc, Zillikens and Stančáková, Alena and Stanč;Ã¡kova, A. and Finucane, Francis M. and Fm, Finucane and Ried, Janina S. and Js, Ried and Langenberg, Claudia and Zhang, Weihua and Beckmann, Jacques S. and Js, Beckmann and Luan, Jian’an and Vandenput, Liesbeth and Styrkársdóttir, Unnur and Zhou, Yanhua and Smith, Albert Vernon and Av, Smith and Zhao, Jing-Hua and Jh, Zhao and Amin, Najaf and Vedantam, Sailaja and Shin, So-Youn and Sy, Shin and Haritunians, Talin and Fu, Mao and Feitosa, Mary F. and Mf, Feitosa and Kumari, Meena and Bv, Halldorsson and Halldorsson, Bjarni V. and Tikkanen, Emmi and Am, Arnold and Mangino, Massimo and Hayward, Caroline and Ys, Aulchenko and Song, Ci and Arnold, Alice M. and Ba, Oostra and Aulchenko, Yurii S. and Oostra, Ben A. and La, Cupples and Campbell, Harry and Cupples, La Adrienne and Ke, Davis and Davis, Kathryn E. and Döring, Angela and Doring, Angela and DÃ¶ring, A. and Eiriksdottir, Gudny and Estrada, Karol and Fernández-Real, José Manuel and Jm, FernÃ¡ndez Real and Garcia, Melissa and Gieger, Christian and Nl, Glazer and Glazer, Nicole L. and Guiducci, Candace and Se, Humphries and Hofman, Albert and Humphries, Steve E. and Lc, Jacobs and Isomaa, Bo and Mk, Karlsson and Jacobs, Leonie C. and Jula, Antti and Kt, Khaw and Karasik, David and Karlsson, Magnus K. and Lj, Kim and Khaw, Kay-Tee and Kim, Lauren J. and KivimÃ¤ki, M. and Kivimaki, Mika and Klopp, Norman and KÃ½hnel, B. and Kühnel, Brigitte and Kuhnel, B. and Kuusisto, Johanna and Ljunggren, Östen and Liu, Yongmei and Ljunggren, Osten and Lorentzon, Mattias and Rn, Luben and Luben, Robert N. and Mcknight, Barbara and MellstrÃ¶m, D. and Mellström, Dan and Mitchell, Braxton D. and Bd, Mitchell and Mooser, Vincent and Moreno, José Maria and Jm, Moreno and Männistö, Satu and Männistö, Satu and O'Connell, Jeffery R. and S., MÃ¤nnistÃ¶ and O’Connell, Jeffery R. and Pascoe, Laura and Peltonen, Leena and Peral, Belén and Perola, Markus and Bm, Psaty and Psaty, Bruce M. and Salomaa, Veikko and Db, Savage and Savage, David B. and Rk, Semple and Semple, Robert K. and Skaric-Juric, Tatjana and Sigurðsson, Gunnar and Ks, Song and Song, Kijoung S. and Td, Spector and Spector, Timothy D. and Ac, SyvÃ¤nen and Syvanen, Ann-Christine and Talmud, Philippa J. and Pj, Talmud and Thorleifsson, Gudmar and Thorsteinsdottir, Unnur and Uitterlinden, Andre G. and van Duijn, Cornelia M. and Ag, Uitterlinden and Cm, van Duijn and Vidal-Puig, Antonio and Wild, Sarah H. and Sh, Wild and Wright, Alan F. and Af, Wright and Clegg, Deborah J. and Dj, Clegg and Schadt, Eric and Wilson, James F. and Jf, Wilson and Rudan, Igor and Ripatti, Samuli and Borecki, Ingrid B. and Ib, Borecki and Shuldiner, Alan R. and Ar, Shuldiner and Ingelsson, Erik and Jansson, John-Olov and Jo, Jansson and Kaplan, Robert C. and Rc, Kaplan and Gudnason, Vilmundur and Harris, Tamara B. and Tb, Harris and Groop, Leif and Kiel, Douglas P. and Dp, Kiel and Rivadeneira, Fernando and Walker, Mark and Barroso, Inês and Vollenweider, Peter and Waeber, Gerard and Jc, Chambers and Chambers, John C. and Kooner, Jaspal S. and Js, Kooner and Soranzo, Nicole and Jn, Hirschhorn and Hirschhorn, Joel N. and Stefansson, Kari and He, Wichmann and Wichmann, He-Erich and Ohlsson, Claes and O’Rahilly, Stephen and O'Rahilly, Stephen and Nj, Wareham and Wareham, Nicholas J. and Ek, Speliotes and Speliotes, Elizabeth K. and Cs, Fox and Fox, Caroline S. and Laakso, Markku and Loos, Ruth J. F. and Rj, Loos},
  doi = {10.1038/ng.866},
  journal = {Nature Genetics},
  month = {jun},
  pages = {753-760},
  title = {Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/21706003},
  volume = {43},
  year = {2011}
}

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