Dissemin is shutting down on January 1st, 2025

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Nature Research, Nature Immunology, 5(16), p. 485-494, 2015

DOI: 10.1038/ni.3132

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Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis

Journal article published in 2015 by Matthew S. Miller, Alexamder Rialdi, Jessica Sook Yuin Ho ORCID, Micah Tilove, Luis Martinez-Gil, Natasha P. Moshkina, Zuleyma Peralta, Justine Noel, Camilla Melegari, Ana M. Maestre, Panagiotis Mitsopoulos, Joaquin Madrenas, Sven Heinz, Chris Benner, John A. T. Young and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we identified a role for SETX in controlling the antiviral response. Cells that had undergone depletion of SETX and SETX-deficient cells derived from patients with AOA2 had higher expression of antiviral mediators in response to infection than did wild-type cells. Mechanistically, we propose a model whereby SETX attenuates the activity of RNA polymerase II (RNAPII) at genes stimulated after a virus is sensed and thus controls the magnitude of the host response to pathogens and the biogenesis of various RNA viruses (e.g., influenza A virus and West Nile virus). Our data indicate a potentially causal link among inborn errors in SETX, susceptibility to infection and the development of neurologic disorders.