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American Chemical Society, Analytical Chemistry, 10(84), p. 4271-4276, 2012

DOI: 10.1021/ac300612y

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Ion Mobility Separation of Variant Histone Tails Extending to the “Middle-down” Range

Journal article published in 2012 by Alexandre A. Shvartsburg, Yupeng Zheng ORCID, Richard D. Smith ORCID, Neil L. Kelleher
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Differential ion mobility spectrometry (FAIMS) can baseline-resolve multiple variants of post-translationally modified peptides extending to the 3 - 4 kDa range, which differ in the localization of a PTM as small as acetylation. Essentially orthogonal separations for different charge states expand the total peak capacity in proportion to the number of observed states that increases for longer polypeptides. This might enable resolving localization variants for yet larger peptides and even intact proteins.