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Public Library of Science, PLoS ONE, 9(7), p. e44796, 2012

DOI: 10.1371/journal.pone.0044796

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Regulation of Energy Metabolism by the Extracytoplasmic Function (ECF) σ Factors of Arcobacter butzleri

Journal article published in 2012 by Irati Martínez Malax-Echevarría, Rudy Muts, Linda van Dijk, Craig T. Parker, William G. Miller, Steven Huynh, Jos P. M. van Putten ORCID, Wim Gaastra, Marc M. S. M. Wösten ORCID, Aurora Fernández Astorga
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

11 p. ; The extracytoplasmic function (ECF) σ factors are fundamental for bacterial adaptation to distinct environments and for survival under different stress conditions. The emerging pathogen Arcobacter butzleri possesses seven putative pairs of σ/anti-σ factors belonging to the ECF family. Here, we report the identification of the genes regulated by five out of the seven A. butzleri ECF σ factors. Three of the ECF σ factors play an apparent role in transport, energy generation and the maintenance of redox balance. Several genes like the nap, sox and tct genes are regulated by more than one ECF σ factor, indicating that the A. butzleri ECF σ factors form a network of overlapping regulons. In contrast to other eubacteria, these A. butzleri ECF regulons appear to primarily regulate responses to changing environments in order to meet metabolic needs instead of an obvious role in stress adaptation.