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Elsevier, European Journal of Medicinal Chemistry, 12(40), p. 1335-1340, 2005

DOI: 10.1016/j.ejmech.2005.05.001

Wiley-VCH Verlag, ChemInform, 18(37), 2006

DOI: 10.1002/chin.200618121

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Synthesis and antimalarial activities of some furoxan sulfones and related furazans

Journal article published in 2005 by Ubaldina Galli, Loretta Lazzarato, Massimo Bertinaria ORCID, Giovanni Sorba, Alberto Gasco, Silvia Parapini ORCID, Donatella Taramelli
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Abstract

Furoxan derivatives bearing a sulfone moiety at position 3 or 4 were synthesized and tested for their antimalarial action on the chloroquine-sensitive D10 and the chloroquine-resistant W2 strains of Plasmodium falciparum. The furazan analogues were considered for comparison. The most active compounds were the products in which the -SO2R groups are at the 3-position of the furoxan system. These latter substances displayed an antimalarial activity in the microM range, possibly related in part to their ability to release NO.