Published in

Springer Nature [academic journals on nature.com], British Journal of Cancer, 9(88), p. 1403-1405, 2003

DOI: 10.1038/sj.bjc.6600919

Links

Tools

Export citation

Search in Google Scholar

Absence of BRAF gene mutations in uveal melanomas in contrast to cutaneous melanomas

Journal article published in 2003 by Edmunds Sc, S. C. Edmunds ORCID, I. A. Cree, Cree Ia, F. Di Nicolantonio, J. L. Hungerford, Hungerford Jl, J. S. Hurren, Hurren Js, Kelsell Dp, D. P. Kelsell
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The recent discovery of activating mutations in the BRAF gene in many cutaneous melanomas led us to screen the genomic sequence of BRAF exons 11 and 15 in a series of 48 intraocular (uveal) melanomas, together with control samples from three cutaneous melanomas and the SK-Mel-28 cell line, which has a BRAF mutation. The same mutation was detected in two-thirds of our cutaneous melanoma samples, but was not present in any uveal melanomas. This finding further underlines the distinction between uveal and cutaneous melanomas, and suggests that BRAF inhibitors are unlikely to benefit patients with uveal melanoma.