Published in

Taylor and Francis Group, Journal of Biological Dynamics, 6(3), p. 574-598, 2009

DOI: 10.1080/17513750902829393

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A mathematical model for malaria involving differential susceptibility, exposedness and infectivity of human host

Journal article published in 2009 by Arnaud Ducrot, S. B. Sirima ORCID, Blaise Some, Pascal Zongo
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The main purpose of this article is to formulate a deterministic mathematical model for the transmission of malaria that considers two host types in the human population. The first type is called "non-immune" comprising all humans who have never acquired immunity against malaria and the second type is called "semi-immune". Non-immune are divided into susceptible, exposed and infectious and semi-immune are divided into susceptible, exposed, infectious and immune. We obtain an explicit formula for the reproductive number, R(0) which is a function of the weight of the transmission semi-immune-mosquito-semi-immune, R(0a), and the weight of the transmission non-immune-mosquito-non-immune, R(0e). Then, we study the existence of endemic equilibria by using bifurcation analysis. We give a simple criterion when R(0) crosses one for forward and backward bifurcation. We explore the possibility of a control for malaria through a specific sub-group such as non-immune or semi-immune or mosquitoes.