BMJ Publishing Group, Gut, 9(54), p. 1232-1236, 2005
Elsevier, Year Book of Gastroenterology, (2006), p. 149-150
DOI: 10.1016/s0739-5930(08)70349-0
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Background and aims: Several antibodies have been reported in the sera of patients with Crohn’s disease (CD) and ulcerative colitis (UC). The most commonly described are anti-Saccharomyces cerevisiae mannan antibodies (ASCA) in CD and perinuclear antineutrophil cytoplasm antibodies (pANCA) in UC. Familial clustering of these antibodies has been described, suggesting they might be genetic markers. Our aim was to investigate the presence of these antibodies before the emergence of overt clinical manifestations.