Published in
BMJ Publishing Group, Gut, 5(54), p. 648-653, 2005
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- BMJ Publishing Group
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- [www.ncbi.nlm.nih.gov] | PDF
- [gut.bmj.com] | PDF
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- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma
Journal article published in 2005 by
R. Al-Ghnaniem 
,
T. A. B. Sanders ,
A. Khushal,
P. Appleby,
N. Harris,
S. Gout,
M. Pufulete,
P. W. Emery
,
T. A. B. Sanders ,
A. Khushal,
P. Appleby,
N. Harris,
S. Gout,
M. Pufulete,
P. W. Emery
This paper is available in a repository.
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Abstract
Background and aims: A low dietary folate intake can cause genomic DNA hypomethylation and may increase the risk of colorectal neoplasia. The hypothesis that folic acid supplementation increases DNA methylation in leucocytes and colorectal mucosa was tested in 31 patients with histologically confirmed colorectal adenoma using a randomised, double blind, placebo controlled, parallel design.