Published in

MDPI, Molecules, 3(18), p. 3479-3501, 2013

DOI: 10.3390/molecules18033479

Links

Tools

Export citation

Search in Google Scholar

Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents

Journal article published in 2013 by Marcos Derita, Esther del Olmo ORCID, Bianca Barboza, Ana Esther García-Cadenas, José Luis López-Pérez, Sebastián Andújar, Daniel Enriz, Susana Zacchino, Arturo San Feliciano, Arturo San Feliciano
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Twenty-five polysubstituted phthalazinone derivatives were synthesized and tested for their antifungal activity against a panel of pathogenic and clinically important yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2- methylphthalazin-1(2H)-one (5) exhibited a remarkable antifungal activity against standardised strains of dermatophytes and Cryptococcus neoformans, as well as against some clinical isolates. A physicochemical study performed on compound 5 revealed its conformational and electronic characteristics, providing us with useful data for the future design of novel related antifungal analogues.