Recently, we proposed a new generic strategy of using chemically inert shell-isolated nanoparticles to obtain surface Raman signals with high sensitivity from various materials and surface species, which could be used in inspecting food safety,drug, security, and environment protection rapidly. We call this new technique the “shell-isolated nanoparticle-enhanced Raman spectroscopy” (SHINERS). It could be applied widely as a simple-to-use tool for industrial and daily inspection applications. This approach can be applied in inspecting pesticide residues on fruit. We spread SHINERS particles over the probed range surface and then took the measurement.